Bus Tickets from San Diego, CA, US to Santa Clara, US

Next departures

Next departures for San Diego to Santa Clara on October 24
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Santa Fe Depot
Santa Ana Regional Transportation CenterCheapestFastest
Amtrak
Santa Fe Depot
Great America StationNo tags
Amtrak
Santa Fe Depot
Santa Clara Transit CenterNo tags

Last refresh of the prices: Last Thursday at 5:27 PM PDT.

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Compare 2 ways to go from San Diego to Santa Clara

Bus
Average Price$14 - $14Average Duration2h 5m
3kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$32 - $32Average Duration1h 54m
12kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from San Diego to Santa Clara

Among the sustainable travel choices, the train stands out as the good way to reach Santa Clara. The journey takes about 1 hour 54 minutes and with fares starting at just $32, it presents an excellent value for a comfortable ride.

22train per day
1h 54mAverage Duration
$32Cheapest ticket
12kgCO₂ emissions

Bus San Diego, CA, US to Santa Clara, US: Trip Overview

Average ticket price$14
Average bus trip duration2h 5m
Number of daily buses1
Earliest bus departure9:25pm
Distance82 miles (132 km)

San Diego to Santa Clara Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Santa Clara is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from San Diego to Santa Clara will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Diego, CA, US - Santa Clara, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/20
$108
10/21
$108
Today
$108
10/23
$108
10/24
$12
10/25
$102
10/26
$108
10/27
$108
busbud logoThe cheapest trip from San Diego, CA, US to Santa Clara, US was searched and found on Oct 24, 2025 with a price of $12

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Clara, US, as early as possible.

You can expect to pay from $12 to $109 for a bus ticket from San Diego, CA, US to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at $12 which is on 2025-10-24.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Santa Clara will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from San Diego, CA, US to Santa Clara, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from Santa Clara, US to San Diego, CA, US

You can also go to Santa Clara, US by train

Train from San Diego, CA, US to Santa Clara, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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