Bus Tickets from San Diego, CA to Santa Clara, CA

Find affordable bus tickets from San Diego, CA to Santa Clara, CA with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayMay 10
TomorrowMay 11
from $108
MonMay 12
TueMay 13
WedMay 14
ThuMay 15
FriMay 16
SatMay 17

Next departures to Santa Clara

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 11 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: May 12 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 11 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: May 12 at
    Destination city: Santa Clara
    Destination location: Santa Clara Transit Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: May 11 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: May 12 at
    Destination city: Santa Clara
    Destination location: Santa Clara Transit Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from San Diego to Santa Clara.

Bus
Average Price$115 - $117Average Duration14h 22m
17kg CO₂e5 out of 5 stars
Train
Average Price$32 - $127Average Duration1h 58m
12kg CO₂e1 out of 5 stars
CheapestFastestMost eco-friendly
busbud logoBusbud recommends taking the train from San Diego to Santa Clara

Among the sustainable travel choices, the train stands out as the good way to reach Santa Clara. The journey takes about 1 hour 58 minutes and with fares starting at just $32, it presents an excellent value for a comfortable ride.

26train per day
1h 58mAverage Duration
$32Cheapest ticket
12kgCO₂ emissions

Bus San Diego to Santa Clara: Trip Overview

Average ticket price$115
Average bus trip duration14h 22m
Number of daily buses2
Earliest bus departure8:45pm
Distance422 miles (680 km)
Latest bus departure9:25pm

San Diego to Santa Clara Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Santa Clara is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from San Diego to Santa Clara will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Diego - Santa Clara

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/08
No data
05/09
$102
Today
$102
05/11
$108
05/12
$108
05/13
$108
05/14
$108
05/15
$108
busbud logoThe cheapest trip from San Diego to Santa Clara was searched and found on May 9, 2025 with a price of $102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Santa Clara, as early as possible.

You can expect to pay from $102 to $108 for a bus ticket from San Diego to Santa Clara based on the last 2 days. You can expect to find the cheapest price for the trip at $108 which is on 2025-05-11.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Santa Clara will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Diego by bus?

Bus from San Diego to Santa Clara

You can also go to Santa Clara by train

Train from San Diego to Santa Clara

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego

Popular Buses Connecting Santa Clara

Buses Leaving from Santa Clara

Buses Going to Santa Clara