Bus Tickets from San Diego (CA), US to Santa Clara (CA), US

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TodayMay 25
from US$120
TomorrowMay 26
TueMay 27
WedMay 28
ThuMay 29
FriMay 30
SatMay 31
SunJun 1

Next departures to Santa Clara

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: May 25 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: May 26 at
    Destination city: Santa Clara
    Destination location: Great America Station
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:
  • Departure time: May 25 at
    Departure city: San Diego
    Departure location: Santa Fe Depot
    Arrival time: May 26 at
    Destination city: Santa Clara
    Destination location: Santa Clara Transit Center
    Operated by: AmtrakAmtrak
    Vehicle: BusDuration:

Last refresh of the prices: Today at 1:06 AM PDT.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from San Diego to Santa Clara

Bus
Average PriceUS$115 - US$117Average Duration14h 22m
17kg CO₂e5 out of 5 stars
Train
Average PriceUS$37 - US$47Average Duration2h 29m
12kg CO₂e1 out of 5 stars
CheapestFastestMost eco-friendly
busbud logoBusbud recommends taking the train from San Diego to Santa Clara

Among the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 2 hours 29 minutes, and with fares starting at just US$37, it presents an excellent value for a comfortable ride.

10train per day
2h 29mAverage Duration
US$37Cheapest ticket
12kgCO₂ emissions

Bus San Diego to Santa Clara: Trip Overview

Average Ticket PriceUS$115
Average Bus Trip Duration14h 22m
Number of daily buses2
Earliest bus departure8:45pm
Distance680 km
Latest bus departure9:25pm

San Diego to Santa Clara Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Santa Clara is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from San Diego to Santa Clara will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip San Diego (CA), US - Santa Clara (CA), US

  1. How long does it take to get to Santa Clara from San Diego by bus?

    The bus ride from San Diego to Santa Clara takes 14h 22m, on average. The fastest bus on this trip will get to Santa Clara in 14h 14m

  2. What is the distance between San Diego and Santa Clara?

    San Diego and Santa Clara are 677 km (420 miles) apart.

  3. How much is the bus from San Diego to Santa Clara?

    The bus from San Diego to Santa Clara will cost you US$115, on average.

  4. Is it possible to travel by overnight bus from San Diego to Santa Clara?

    Yes! If you're heading from San Diego to Santa Clara, you'll find buses departing until 9:25pm and arriving the next day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-23
US$109
05-24
US$112
Today
US$114
05-26
US$110
05-27
US$108
05-28
US$108
05-29
US$108
05-30
US$102
busbud logoThe cheapest trip from San Diego to Santa Clara was searched and found on May 30, 2025 with a price of US$102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Santa Clara, as early as possible.

You can expect to pay from US$102 to US$115 for a bus ticket from San Diego to Santa Clara based on the last 2 days. You can expect to find the cheapest price for the trip at US$102 which is on 2025-05-30.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Santa Clara will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Diego by bus?

Bus from San Diego to Santa Clara

You can also go to Santa Clara by train

Train from San Diego to Santa Clara

Why choose Busbud?

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