Next departures to Santa Clara
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: July 10 atDeparture city: San DiegoDeparture location: Santa Fe DepotArrival time: July 11 atDestination city: Santa ClaraDestination location: Great America StationOperated by: Amtrak
Vehicle: BusDuration: - This trip is recommended because it is the: FastestDeparture time: July 10 atDeparture city: San DiegoDeparture location: Santa Fe DepotArrival time: July 11 atDestination city: Santa ClaraDestination location: Santa Clara Transit CenterOperated by: AmtrakVehicle: BusDuration:
- Departure time: July 10 atDeparture city: San DiegoDeparture location: Santa Fe DepotArrival time: July 11 atDestination city: Santa ClaraDestination location: Santa Clara Transit CenterOperated by: AmtrakVehicle: BusDuration:
Last refresh of the prices: 2025-07-02 PDT.
Prices and availability are subject to change.
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Compare 2 ways to go from San Diego to Santa Clara
Busbud recommends taking the train from San Diego to Santa ClaraAmong the sustainable travel choices, the train stands out as a good way to reach Santa Clara. The journey takes about 1 hour 54 minutes, and with fares starting at just US$32, it presents an excellent value for a comfortable ride.
Bus San Diego to Santa Clara: Trip Overview
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Based on 5286 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at US$115
San Diego to Santa Clara Bus
With Busbud, comparing and booking tickets for a bus from San Diego to Santa Clara is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from San Diego to Santa Clara will be provided by the most trusted bus companies.
Discover how much the bus trip from San Diego to Santa Clara will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Frequently asked questions on the trip San Diego, CA, US - Santa Clara, US
What is the distance between San Diego and Santa Clara?
San Diego and Santa Clara are 677 km (420 miles) apart.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego to Santa Clara was searched and found on Jul 11, 2025 with a price of US$102To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Santa Clara, as early as possible.
You can expect to pay from US$102 to US$110 for a bus ticket from San Diego to Santa Clara based on the last 2 days. You can expect to find the cheapest price for the trip at US$102 which is on 2025-07-11.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Santa Clara will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Top travelled bus routes
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Popular Buses Connecting San Diego
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Buses Going to San Diego
Popular Buses Connecting Santa Clara
Buses Leaving from Santa Clara
- Bus from Santa Clara to San Jose
- Bus Santa Clara - Santa Barbara
- Santa Clara - San Francisco
- Bus from Santa Clara to Fremont
- Bus Santa Clara - Los Angeles
- Santa Clara - Chico
- Bus from Santa Clara to Eugene
- Bus Santa Clara - Napa
- Santa Clara - Sacramento
- Bus from Santa Clara to Riverside
- Bus Santa Clara - Denver
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Buses Going to Santa Clara
- Bus from San Francisco to Santa Clara
- Bus Sacramento - Santa Clara
- Eugene - Santa Clara
- Bus from San Diego to Santa Clara
- Bus St. Louis - Santa Clara
- Fremont - Santa Clara
- Bus from Berkeley to Santa Clara
- Bus Bakersfield - Santa Clara
- Stockton - Santa Clara
- Bus from Guadalupe to Santa Clara
- Bus Fresno - Santa Clara
- Truckee - Santa Clara
- Bus from Moorpark to Santa Clara
- Bus Reno - Santa Clara
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