Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Madrid (South) | CheapestFastest | ||||
| Bus | Santander (Estacion de Autobuses) | Madrid (South) | No tags |
Last refresh of the prices: Yesterday at 9:03 PM CET.
Compare 3 ways to travel from Santander to Madrid
Among the sustainable travel choices, the Carpool stands out as a good way to reach Madrid. The journey takes about 4 hours 30 minutes and with fares starting at just R 320, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santander and Madrid?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- B
Santander Airport
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Madrid
- APlaza Moncloa, 671, 28008 Madrid, Spain
- BAvenida de América, 9, 28002 Madrid, Spain
- DMendez Alvaro, 83, , Madrid, 28045, Spain
- E
Madrid Interc. Plaza Castilla
Madrid Interc. Plaza Castilla, 28046 Madrid, Spain - FMadrid Atocha railway station, Plaza del Emperador Carlos V, 28045 Madrid, Spain
Compare bus companies
Frequently asked questions about travelling from Santander to Madrid by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Santander to Madrid?
The cheapest bus tickets from Santander to Madrid start at R 701. The average price for this route is around R 870. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Santander to Madrid?
The average bus journey time from Santander to Madrid is 5h 40m, covering a distance of 337 km. The fastest bus gets you there in 4h 30m and is operated by ALSA.
Which bus companies service the Santander to Madrid route?
What is the earliest and latest departure time for the bus from Santander to Madrid?
The earliest bus departs from Santander to Madrid at 00:45. And the latest bus departs at 18:55.
What are the CO₂ emissions for the bus trip from Santander to Madrid?
A bus trip from Santander to Madrid produces an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Santander to Madrid?
According to Busbud customers, the highest-rated bus company on this route is ALSA, with an average rating of 4.3 out of 5 stars based on 61149 reviews.
Which bus company has the best Wi-Fi from Santander to Madrid?
Based on reviews on Busbud, the bus company ALSA has the best Wi-Fi rating with a score of 3.5.
Which bus company offers the most punctual service from Santander to Madrid?
According to Busbud traveller reviews, the most punctual bus company on this route is ALSA, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Santander to Madrid?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Madrid was searched and found on 01 Feb 2026 with a price of R 681To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Madrid as early as possible.
You can expect to pay from R 681 to R 1 640 for a bus ticket from Santander to Madrid based on the last 2 days. You can expect to find the cheapest price for the trip at R 681, which is on 2026-02-01.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
