Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santander (Estacion de Autobuses) | Avenida de América Metro | Cheapest | ||||
 | Bus | Santander (Estacion de Autobuses) | Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4 | Fastest | ||||
| Bus | Santander (Estacion de Autobuses) | Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4 | No tags | ||||
 | Bus | Santander (Estacion de Autobuses) | Madrid (South) | No tags | ||||
| Bus | Santander (Estacion de Autobuses) | Avenida de América Metro | No tags |
Last refresh of the prices: Today at 8:36 AM CET.
Compare 3 ways to go from Santander to Madrid
Among the sustainable travel choices, the Carpool stands out as a good way to reach Madrid. The journey takes about 4 hours 30 minutes, and with fares starting at just $28, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santander and Madrid?
Stops in Santander
- ACalle Navas de Tolosa, 2, 39002 Santander, Cantabria, Spain
- C
Av. de los Castros 43A
Av. de los Castros 43A, 39005 Santander, Cantabria, Spain - D
Calle Camarreal-Ojaiz
Calle Camarreal-Ojaiz, 52, 39011 Santander, Cantabria, Spain - E
Av. de Pontejos
Av. de Pontejos, 33A, 39005 Santander, Cantabria, Spain - F
Estación Marítima
39002 Santander, Cantabria, Spain
Stops in Madrid
- AAvenida de América, 9, 28002 Madrid, Spain
- CPlaza Moncloa, 671, 28008 Madrid, Spain
- DMendez Alvaro, 83, , Madrid, 28045, Spain
- E
Madrid Interc. Plaza Castilla
Madrid Interc. Plaza Castilla, 28046 Madrid, Spain - FMadrid Atocha railway station, Plaza del Emperador Carlos V, 28045 Madrid, Spain
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Frequently asked questions about travelling from Santander to Madrid by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santander to Madrid?
The cheapest bus tickets from Santander to Madrid start from $57. The average price for this route is around $76. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santander to Madrid?
The average bus travel time from Santander to Madrid is 5h 40m, covering a distance of 337 km. The quickest bus can get you there in 4h 30m and is operated by ALSA.
Which bus companies service the Santander to Madrid route?
What are the earliest and latest departure times for the bus from Santander to Madrid?
The earliest bus departs from Santander to Madrid at 12:45am. And the latest bus departs at 6:50pm.
What are the CO₂ emissions for the bus trip from Santander to Madrid?
A bus trip from Santander to Madrid generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Santander to Madrid?
According to Busbud customers, the highest-rated bus company on this route is ALSA, with an average rating of 4.3 out of 5 stars based on 61288 reviews.
Which bus company has the best Wi-Fi from Santander to Madrid?
Based on Busbud reviews, the bus company ALSA has the highest Wi-Fi rating with a score of 3.5.
Which bus company has the best on-time performance from Santander to Madrid?
According to Busbud traveller reviews, the most punctual bus company on this route is ALSA, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Santander to Madrid?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is ALSA, with a cleanliness rating of 4.7 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santander to Madrid was searched and found on Feb 20, 2026 with a price of $56To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Madrid, as early as possible.
You can expect to pay from $56 to $313 for a bus ticket from Santander to Madrid based on the last 2 days. You can expect to find the cheapest price for the trip at $56 which is on 2026-02-20.
