Find coaches from St. Louis to Jacksonville, FL

Next departures

Next departures from St. Louis to Jacksonville on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Gateway Station
Jacksonville Bus StationCheapest
FlixBus + Greyhound Lines, Inc.
Gateway Station
Jacksonville Bus StationFastest
FlixBus + Greyhound Lines, Inc.
Gateway Station
Jacksonville Bus StationNo tags

Last refresh of the prices: Last Monday at 5:48 PM CDT.

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Compare 2 ways to travel from St. Louis to Jacksonville

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 22 hours 50 minutes and with fares starting at just US$76, it presents an excellent value for a comfortable ride.

2bus per day
22h 50mAverage duration
1208 kmDistance
30kgCO₂ emissions
Bus
Average priceUS$76 - US$382Average duration22h 50m
30kg CO₂e
Train
Average priceUS$161 - US$2 983Average duration1d 22h
109kg CO₂e

Bus St. Louis to Jacksonville, FL: Trip Overview

Average ticket priceUS$140
Average bus trip duration22h 50m
Number of daily buses2
Earliest bus departure02:00
Distance1208 km
Latest bus departure23:30

St. Louis to Jacksonville Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Jacksonville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Jacksonville.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Jacksonville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Jacksonville, FL

  1. How much does a bus ticket from St. Louis to Jacksonville cost?

    The bus ticket price from St. Louis to Jacksonville starts at US$76. The best way to find cheap bus tickets from St. Louis to Jacksonville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from St. Louis to Jacksonville?

    The average travel time between St. Louis and Jacksonville is around 22h 50m, although the fastest bus will take about 19h 50m. This is the time it takes to travel the 1211 km that separates the two cities.

  3. How many daily bus connections are there between St. Louis and Jacksonville?

    The number of buses from St. Louis to Jacksonville can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Jacksonville by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from St. Louis to Jacksonville?

    When taking the bus from St. Louis to Jacksonville, you can travel comfortably and safely with FlixBus, Greyhound.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
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30/10
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Today
No data
01/11
No data
02/11
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03/11
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04/11
US$140
05/11
US$135
busbud logoThe cheapest trip from St. Louis to Jacksonville, FL was searched and found on 05 Nov 2025 with a price of US$135

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Jacksonville, FL as early as possible.

You can expect to pay from US$135 to US$140 for a bus ticket from St. Louis to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$135, which is on 2025-11-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St. Louis to Jacksonville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Jacksonville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Jacksonville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Jacksonville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from St. Louis to Jacksonville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Jacksonville, FL to St. Louis

You can also go to Jacksonville, FL by train

Train from St. Louis to Jacksonville, FL

Why choose Busbud?

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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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