Cheap buses leaving Thursday
One passenger / one way
- This trip is recommended because it is the: CheapestDeparture time: July 17 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: July 18 atDestination city: JacksonvilleDestination location: Jacksonville Bus StationOperated by: FlixBus
Vehicle: BusDuration: - This trip is recommended because it is the: FastestDeparture time: July 17 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: July 18 atDestination city: JacksonvilleDestination location: Jacksonville Bus StationOperated by: FlixBusVehicle: BusDuration:
- Departure time: July 17 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: July 18 atDestination city: JacksonvilleDestination location: Jacksonville Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: July 17 atDeparture city: St. LouisDeparture location: Gateway StationArrival time: July 18 atDestination city: JacksonvilleDestination location: Jacksonville Bus StationOperated by: FlixBusVehicle: BusDuration:
Last refresh of the prices: Last Thursday at 6:10 PM CDT.
Prices and availability are subject to change.
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Compare 2 ways to go from St. Louis to Jacksonville
Busbud recommends taking the bus from St. Louis to JacksonvilleAmong the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 22 hours, and with fares starting at just US$91, it presents an excellent value for a comfortable ride.
Bus St. Louis to Jacksonville: Trip Overview
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St. Louis to Jacksonville Bus
With Busbud, comparing and booking tickets for a bus from St. Louis to Jacksonville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Jacksonville.
From cheap bus tickets to more luxurious buses travelling from St. Louis to Jacksonville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in St. Louis and Jacksonville?
Frequently asked questions on the trip St. Louis - Jacksonville, FL
What is the distance between St. Louis and Jacksonville?
The distance covered from St. Louis to Jacksonville is 1211 km (751 miles).
What are the departure and arrival locations for buses traveling from St. Louis to Jacksonville?
Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at Jacksonville Amtrak Station, in Jacksonville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Jacksonville was searched and found on Jul 17, 2025 with a price of US$111To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Jacksonville, as early as possible.
You can expect to pay from US$111 to US$148 for a bus ticket from St. Louis to Jacksonville based on the last 2 days. You can expect to find the cheapest price for the trip at US$111 which is on 2025-07-17.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from St. Louis to Jacksonville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Jacksonville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Jacksonville that are otherwise impossible to come by with a plane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Jacksonville.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
What's the cheapest way to go from St. Louis to Jacksonville?
The bus is the cheapest travel choice for this destinationTop travelled bus routes
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