Bus Tickets from St. Louis to Jacksonville, FL

Previously seen trips

Next departures for St. Louis to Jacksonville on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Gateway Station
Jacksonville Bus StationNo tags
FlixBus + Greyhound
Gateway Station
Jacksonville Bus StationNo tags
Greyhound
Gateway Station
Jacksonville Bus StationNo tags
Greyhound
Gateway Station
Jacksonville Bus StationNo tags
Greyhound + FlixBus
Gateway Station
Jacksonville Bus StationNo tags

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from St. Louis to Jacksonville

Bus
Average PriceUS$76 - US$382Average Duration20h 35m
30kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$234 - US$1,862Average Duration1d 21h
109kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to Jacksonville

Among the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 20 hours 35 minutes, and with fares starting at just US$76, it presents an excellent value for a comfortable ride.

2bus per day
20h 35mAverage Duration
US$76Cheapest ticket
30kgCO₂ emissions

Bus St. Louis to Jacksonville, FL: Trip Overview

Average Ticket PriceUS$125
Average Bus Trip Duration20h 35m
Number of daily buses2
Earliest bus departure2:00am
Distance1208 km
Latest bus departure11:30pm

St. Louis to Jacksonville Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Jacksonville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Jacksonville.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Jacksonville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Jacksonville, FL

  1. What is the distance between St. Louis and Jacksonville?

    The distance covered from St. Louis to Jacksonville is 1211 km (751 miles).

  2. What are the departure and arrival locations for buses traveling from St. Louis to Jacksonville?

    Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at Jacksonville Amtrak Station, in Jacksonville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-10
US$233
10-11
US$146
Today
US$144
10-13
No data
10-14
No data
10-15
No data
10-16
No data
10-17
No data
busbud logoThe cheapest trip from St. Louis to Jacksonville, FL was searched and found on Oct 12, 2025 with a price of US$144

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Jacksonville, FL, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St. Louis to Jacksonville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Jacksonville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Jacksonville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Jacksonville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from St. Louis to Jacksonville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Jacksonville, FL to St. Louis

You can also go to Jacksonville, FL by train

Train from St. Louis to Jacksonville, FL

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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