Bus Tickets from St. Louis to Jacksonville, FL

Find affordable bus tickets from St. Louis to Jacksonville, FL with flexible options. Book your trip now

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TodayAug 28
TomorrowAug 29
SatAug 30
SunAug 31
from US$101
MonSep 1
TueSep 2
WedSep 3
ThuSep 4

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: August 31 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 1 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 1 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 1 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: August 31 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 1 at
    Destination city: Jacksonville
    Destination location: Jacksonville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from St. Louis to Jacksonville

Bus
Average PriceUS$86 - US$215Average Duration22h 50m
30kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$188 - US$1,900Average Duration1d 21h
109kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to Jacksonville

Among the sustainable travel choices, the bus stands out as a good way to reach Jacksonville. The journey takes about 22 hours 50 minutes, and with fares starting at just US$86, it presents an excellent value for a comfortable ride.

4bus per day
22h 50mAverage Duration
US$86Cheapest ticket
30kgCO₂ emissions

Bus St. Louis to Jacksonville, FL: Trip Overview

Average Ticket PriceUS$123
Average Bus Trip Duration22h 50m
Number of daily buses4
Earliest bus departure8:30am
Distance1208 km
Latest bus departure11:30pm

St. Louis to Jacksonville Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Jacksonville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from St. Louis to Jacksonville.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Jacksonville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Jacksonville, FL

  1. What is the distance between St. Louis and Jacksonville?

    The distance covered from St. Louis to Jacksonville is 1211 km (751 miles).

  2. What are the departure and arrival locations for buses traveling from St. Louis to Jacksonville?

    Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at Jacksonville Amtrak Station, in Jacksonville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-26
US$104
08-27
US$78
Today
No data
08-29
No data
08-30
No data
08-31
US$94
09-01
No data
09-02
No data
busbud logoThe cheapest trip from St. Louis to Jacksonville, FL was searched and found on Aug 27, 2025 with a price of US$78

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Jacksonville, FL, as early as possible.

You can expect to pay from US$78 to US$116 for a bus ticket from St. Louis to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at US$94 which is on 2025-08-31.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St. Louis to Jacksonville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from St. Louis to Jacksonville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Jacksonville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to Jacksonville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from St. Louis to Jacksonville, FL?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Jacksonville, FL to St. Louis

You can also go to Jacksonville, FL by train

Train from St. Louis to Jacksonville, FL

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