Find coaches from St. Louis to Syracuse, US

Next departures

Next departures from St. Louis to Syracuse on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Gateway Station
Syracuse (Regional Transportation Center)CheapestFastest
Greyhound Lines, Inc.
Gateway Station
Syracuse (Regional Transportation Center)No tags

Last refresh of the prices: Last Tuesday at 10:48 AM CDT.

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Compare 2 ways to travel from St. Louis to Syracuse

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Syracuse. The journey takes about 1 day, 5 hours 40 minutes and with fares starting at just US$93, it presents an excellent value for a comfortable ride.

1bus per day
1d 5hAverage duration
1278 kmDistance
32kgCO₂ emissions
Bus
Average priceUS$93 - US$289Average duration1d 5h
32kg CO₂e
Train
Average priceUS$112 - US$884Average duration1d 2h
116kg CO₂e

Bus St. Louis to Syracuse, US: Trip Overview

Average ticket priceUS$143
Average bus trip duration1d 5h
Number of daily buses1
Earliest bus departure08:45
Distance1278 km
Latest bus departure13:55

St. Louis to Syracuse Bus

Busbud helps you find a bus from St. Louis to Syracuse. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from St. Louis to Syracuse from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Syracuse from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - Syracuse, US

  1. How much does a bus ticket from St. Louis to Syracuse cost?

    The bus ticket price from St. Louis to Syracuse starts at US$93. The best way to find cheap bus tickets from St. Louis to Syracuse is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from St. Louis to Syracuse?

    The average travel time between St. Louis and Syracuse is around 1d 5h, although the fastest bus will take about 1d 5h. This is the time it takes to travel the 1280 km that separates the two cities.

  3. How many daily bus connections are there between St. Louis and Syracuse?

    The number of buses from St. Louis to Syracuse can differ depending on the day of the week. On average, there are 1 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from St. Louis to Syracuse by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from St. Louis to Syracuse?

    When taking the bus from St. Louis to Syracuse, you can travel comfortably and safely with Greyhound.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/10
US$119
30/10
US$129
Today
US$186
01/11
US$115
02/11
No data
03/11
No data
04/11
No data
05/11
No data
busbud logoThe cheapest trip from St. Louis to Syracuse, US was searched and found on 01 Nov 2025 with a price of US$115

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Syracuse, US as early as possible.

You can expect to pay from US$115 to US$186 for a bus ticket from St. Louis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$115, which is on 2025-11-01.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Syracuse!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Syracuse, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Syracuse.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Syracuse while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from St. Louis to Syracuse, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Syracuse, US to St. Louis

You can also go to Syracuse, US by train

Train from St. Louis to Syracuse, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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