Bus Tickets from St. Louis to Syracuse, US

Next departures

Next departures for St. Louis to Syracuse on September 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Gateway Station
Syracuse (Regional Transportation Center)CheapestFastest
Greyhound Lines, Inc. + FlixBus
Gateway Station
Syracuse (Regional Transportation Center)No tags
Greyhound Lines, Inc.
Gateway Station
Syracuse (Regional Transportation Center)No tags

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from St. Louis to Syracuse

Bus
Average PriceUS$88 - US$202Average Duration1d 3h
32kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$100 - US$910Average Duration1d 2h
116kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from St. Louis to Syracuse

Among the sustainable travel choices, the bus stands out as a good way to reach Syracuse. The journey takes about 1 day, 3 hours 25 minutes, and with fares starting at just US$88, it presents an excellent value for a comfortable ride.

2bus per day
1d 3hAverage Duration
US$88Cheapest ticket
32kgCO₂ emissions

Bus St. Louis to Syracuse, US: Trip Overview

Average Ticket PriceUS$141
Average Bus Trip Duration1d 3h
Number of daily buses2
Earliest bus departure8:45am
Distance1278 km
Latest bus departure11:30pm

St. Louis to Syracuse Bus

Busbud helps you find a bus from St. Louis to Syracuse. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from St. Louis to Syracuse from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Syracuse from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - Syracuse, US

  1. What is the distance between St. Louis and Syracuse?

    The distance between St. Louis and Syracuse is approximately 1280 km (794 miles).

  2. What are the departure and arrival locations for buses traveling from St. Louis to Syracuse?

    Buses departing from Gateway Station in St. Louis will take you to Syracuse Airport in Syracuse.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-29
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08-30
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Today
No data
09-01
US$148
09-02
No data
09-03
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09-04
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09-05
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busbud logoThe cheapest trip from St. Louis to Syracuse, US was searched and found on Sep 1, 2025 with a price of US$148

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Syracuse, US, as early as possible.

You can expect to pay from US$148 to US$148 for a bus ticket from St. Louis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$148 which is on 2025-09-01.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Syracuse!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Syracuse, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Syracuse.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Syracuse while indulging in miles on end of beautiful scenic views.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from St. Louis to Syracuse, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from Syracuse, US to St. Louis

You can also go to Syracuse, US by train

Train from St. Louis to Syracuse, US

Why choose Busbud?

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