Bus Tickets from St. Louis to Syracuse, US

Previously seen trips

Next departures for St. Louis to Syracuse on November 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
    		Gateway Station
    		Syracuse (Regional Transportation Center)No tags
    Greyhound
      		Gateway Station
      		Syracuse (Regional Transportation Center)No tags
      Greyhound
        		Gateway Station
        		Syracuse (Regional Transportation Center)No tags
        Greyhound
          		Gateway Station
          		Syracuse (Regional Transportation Center)No tags
          Greyhound
            		Gateway Station
            		Syracuse (Regional Transportation Center)No tags

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Compare 2 ways to go from St. Louis to Syracuse

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Syracuse. The journey takes about 1 day, 5 hours 40 minutes, and with fares starting at just US$93, it presents an excellent value for a comfortable ride.

            1bus per day
            1d 5hAverage Duration
            1278 kmDistance
            32kgCO₂ emissions
            Bus
            		Average PriceUS$93 - US$289Average Duration1d 5h
            32kg CO₂e
            Train
            		Average PriceUS$112 - US$884Average Duration1d 2h
            116kg CO₂e

            Bus St. Louis to Syracuse, US: Trip Overview

            Average Ticket PriceUS$143
            Average Bus Trip Duration1d 5h
            Number of daily buses1
            Earliest bus departure8:45am
            Distance1278 km
            Latest bus departure1:55pm

            St. Louis to Syracuse Bus

            Busbud helps you find a bus from St. Louis to Syracuse. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make sure you can find a bus service from St. Louis to Syracuse from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to Syracuse from St. Louis, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip St. Louis - Syracuse, US

            1. What is the distance between St. Louis and Syracuse?

              The distance between St. Louis and Syracuse is approximately 1280 km (794 miles).

            2. What are the departure and arrival locations for buses traveling from St. Louis to Syracuse?

              Buses departing from Gateway Station in St. Louis will take you to Regional Transportation Center in Syracuse.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10-29
            US$119
            10-30
            US$129
            Today
            US$186
            11-01
            US$115
            11-02
            No data
            11-03
            No data
            11-04
            No data
            11-05
            No data
            busbud logoThe cheapest trip from St. Louis to Syracuse, US was searched and found on Nov 1, 2025 with a price of US$115

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Syracuse, US, as early as possible.

            You can expect to pay from US$115 to US$186 for a bus ticket from St. Louis to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$115 which is on 2025-11-01.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between St. Louis and Syracuse!

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Syracuse, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Syracuse.

            Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Syracuse while indulging in miles on end of beautiful scenic views.

            Did you know?

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            What's the cheapest way to go from St. Louis to Syracuse, US?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to St. Louis by bus?

            Bus from Syracuse, US to St. Louis

            You can also go to Syracuse, US by train

            Train from St. Louis to Syracuse, US

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