Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Tupelo (Brothers Quick Stop) | CheapestFastest |
Last refresh of the prices: Yesterday at 4:54 PM CST.
Get from St. Louis to Tupelo
The journey takes about 7 hours 5 minutes, and with fares starting at just R 1 833, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87479 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 1 910
Frequently asked questions about travelling from St. Louis to Tupelo by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from St. Louis to Tupelo?
The cheapest bus tickets from St. Louis to Tupelo start at R 1 833. The average price for this route is around R 2 003. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from St. Louis to Tupelo?
The average bus journey time from St. Louis to Tupelo is 7h 5m, covering a distance of 507 km. The fastest bus gets you there in 9h 40m and is operated by Greyhound.
Which bus companies service the St. Louis to Tupelo route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from St. Louis to Tupelo?
The earliest bus departs from St. Louis to Tupelo at 01:00. And the latest bus departs at 16:00.
What are the CO₂ emissions for the bus trip from St. Louis to Tupelo?
A bus trip from St. Louis to Tupelo produces an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Tupelo was searched and found on 08 Jan 2026 with a price of R 1 127To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Tupelo as early as possible.
You can expect to pay from R 1 127 to R 2 085 for a bus ticket from St. Louis to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 127, which is on 2026-01-08.
