Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Tupelo (Brothers Quick Stop) | CheapestFastest |
Last refresh of the prices: Last Thursday at 9:18 AM CST.
Get from St. Louis to Tupelo
The journey takes about 9 hours 40 minutes, and with fares starting at just $88, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87523 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. Greyhound ticket prices on this trip start at $88
Frequently asked questions about travelling from St. Louis to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Tupelo?
The cheapest bus tickets from St. Louis to Tupelo start from $88. The average price for this route is around $122. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Tupelo?
The average bus travel time from St. Louis to Tupelo is 9h 40m, covering a distance of 507 km. The quickest bus can get you there in 9h 40m and is operated by Greyhound.
Which bus companies service the St. Louis to Tupelo route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from St. Louis to Tupelo?
The earliest bus departs from St. Louis to Tupelo at 1:00am. And the latest bus departs at 4:00pm.
What are the CO₂ emissions for the bus trip from St. Louis to Tupelo?
A bus trip from St. Louis to Tupelo generates an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Tupelo was searched and found on Feb 15, 2026 with a price of $96To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Tupelo, as early as possible.
You can expect to pay from $96 to $131 for a bus ticket from St. Louis to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $131 which is on 2026-02-18.
