Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound + FlixBus | Bus | Tampa Bus Station | Florence, SC | No tags | ||||
FlixBus + Greyhound | Bus | Tampa Bus Station | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | University of South Florida | Florence, SC | No tags | ||||
FlixBus + Greyhound | Bus | University of South Florida | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | University of South Florida | Bus station | No tags |
Compare 2 ways to travel from Tampa to Florence
Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 20 hours 5 minutes and with fares starting at just R 1 363, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Florence?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling from Tampa to Florence, SC, US by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Tampa to Florence?
The cheapest bus tickets from Tampa to Florence start at R 1 363. The average price for this route is around R 1 888. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Tampa to Florence?
The average bus journey time from Tampa to Florence is 20h 5m, covering a distance of 740 km. The fastest bus gets you there in 12h 57m and is operated by Amtrak.
Which bus companies service the Tampa to Florence route?
What is the earliest and latest departure time for the bus from Tampa to Florence?
The earliest bus departs from Tampa to Florence at 09:30. And the latest bus departs at 22:35.
What are the CO₂ emissions for the bus trip from Tampa to Florence?
A bus trip from Tampa to Florence produces an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Tampa to Florence?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from Tampa to Florence?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Tampa to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Florence, SC, US was searched and found on 16 Dec 2025 with a price of R 1 257To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US as early as possible.
You can expect to pay from R 1 257 to R 7 197 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 257, which is on 2025-12-16.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Tampa to Florence, SC, US?
The bus is the cheapest travel choice for this destination
