Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound | Bus | Tampa Bus Station | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | Tampa Bus Station | Florence, SC | No tags | ||||
Greyhound + FlixBus | Bus | University of South Florida | Bus station | No tags | ||||
Greyhound + FlixBus | Bus | University of South Florida | Florence, SC | No tags | ||||
FlixBus + Greyhound | Bus | University of South Florida | Florence, SC | No tags |
Compare 2 ways to go from Tampa to Florence
Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 20 hours 5 minutes, and with fares starting at just $112, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Florence?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling from Tampa to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tampa to Florence?
The cheapest bus tickets from Tampa to Florence start from $112. The average price for this route is around $150. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tampa to Florence?
The average bus travel time from Tampa to Florence is 20h 5m, covering a distance of 727 km. The quickest bus can get you there in 12h 57m and is operated by Amtrak.
Which bus companies service the Tampa to Florence route?
What are the earliest and latest departure times for the bus from Tampa to Florence?
The earliest bus departs from Tampa to Florence at 9:30am. And the latest bus departs at 10:35pm.
What are the CO₂ emissions for the bus trip from Tampa to Florence?
A bus trip from Tampa to Florence generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Tampa to Florence?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from Tampa to Florence?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Tampa to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Florence, SC, US was searched and found on Dec 16, 2025 with a price of $104To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US, as early as possible.
You can expect to pay from $104 to $590 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $111 which is on 2025-12-17.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Tampa to Florence, SC, US?
The bus is the cheapest travel choice for this destination
