Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Gateway Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Gateway Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Gateway Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Gateway Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Gateway Station | No tags |
Get from Tupelo to St. Louis
The journey takes about 18 hours 20 minutes, and with fares starting at just R 1 996, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87501 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 1 996
Frequently asked questions about travelling from Tupelo to St. Louis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Tupelo to St. Louis?
The cheapest bus tickets from Tupelo to St. Louis start at R 1 996. The average price for this route is around R 2 113. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Tupelo to St. Louis?
The average bus journey time from Tupelo to St. Louis is 18h 20m, covering a distance of 507 km. The fastest bus gets you there in 18h 20m and is operated by Greyhound.
Which bus companies service the Tupelo to St. Louis route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Tupelo to St. Louis?
The earliest bus departs from Tupelo to St. Louis at 05:35. And the latest bus departs at 21:35.
What are the CO₂ emissions for the bus trip from Tupelo to St. Louis?
A bus trip from Tupelo to St. Louis produces an estimated 13 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to St. Louis was searched and found on 16 Jan 2026 with a price of R 1 951To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to St. Louis as early as possible.
You can expect to pay from R 1 951 to R 1 951 for a bus ticket from Tupelo to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 951, which is on 2026-01-16.
