Find coaches from Greenville, SC to St. Louis

Next departures

Next departures from Greenville to St. Louis on 7 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
    		1116 Woodruff Rd
    		Gateway StationCheapestFastest
    FlixBus + Greyhound Lines, Inc.
      		1116 Woodruff Rd
      		Gateway StationNo tags

      Last refresh of the prices: Last Friday at 11:39 AM EDT.

      Accepted payments

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      Compare 2 ways to travel from Greenville to St. Louis

      We recommend taking the bus

      Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 1 hour 35 minutes and with fares starting at just US$110, it presents an excellent value for a comfortable ride.

      2bus per day
      1d 1hAverage duration
      821 kmDistance
      21kgCO₂ emissions
      Bus
      		Average priceUS$110 - US$269Average duration1d 1h
      21kg CO₂e
      Train
      		Average priceUS$417 - US$586Average duration1d 17h
      74kg CO₂e

      Bus Greenville, SC to St. Louis: Trip Overview

      Average ticket priceUS$142
      Average bus trip duration1d 1h
      Number of daily buses2
      Earliest bus departure13:25
      Distance820 km
      Latest bus departure22:00

      Greenville to St. Louis Bus

      With Busbud, comparing and booking tickets for a bus from Greenville to St. Louis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

      Bus service from Greenville to St. Louis will be provided by the most trusted bus companies.

      Whether it is cheap bus tickets or more luxurious buses going to St. Louis from Greenville, we help you find what you're looking for based on how much of a budget you have.

      Frequently asked questions on the trip Greenville, SC - St. Louis

      1. How much does a bus ticket from Greenville to St. Louis cost?

        The bus ticket price from Greenville to St. Louis starts at US$110. The best way to find cheap bus tickets from Greenville to St. Louis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

      2. How long is the bus ride from Greenville to St. Louis?

        The average travel time between Greenville and St. Louis is around 1d 1h, although the fastest bus will take about 14h 25m. This is the time it takes to travel the 813 km that separates the two cities.

      3. How many daily bus connections are there between Greenville and St. Louis?

        The number of buses from Greenville to St. Louis can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Greenville to St. Louis by comparing and selecting the bus that fits your travel style and budget on Busbud.

      4. Which bus companies travel from Greenville to St. Louis?

        When taking the bus from Greenville to St. Louis, you can travel comfortably and safely with FlixBus, Greyhound.

      5. What are the departure and arrival stations when taking the bus from Greenville to St. Louis?

        Buses travelling between Greenville and St. Louis leave from Guadalajara Supermarket Bus Stop or Greenville Bus Station and arrive at Gateway Station.

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
      01/11
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      Today
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      07/11
      US$98
      08/11
      No data
      busbud logoThe cheapest trip from Greenville, SC to St. Louis was searched and found on 07 Nov 2025 with a price of US$98

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to St. Louis as early as possible.

      You can expect to pay from US$98 to US$98 for a bus ticket from Greenville, SC to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$98, which is on 2025-11-07.

      About Bus Travel

      Bus Travel Tips

      Meet and talk to locals at the bus stations while travelling from Greenville to St. Louis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

      Much more than a mere vehicle taking you from Greenville to St. Louis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

      Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to St. Louis.

      Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to St. Louis.

      Did you know?

      The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

      The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

      The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

      What's the cheapest way to go from Greenville, SC to St. Louis?

      busbud logoThe bus is the cheapest travel choice for this destination

      Will you be returning to Greenville, SC by bus?

      Bus from St. Louis to Greenville, SC

      You can also go to St. Louis by train

      Train from Greenville, SC to St. Louis

      Why choose Busbud?

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