Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Bus station | Cheapest | ||||
 | Bus | Newark (DE) | Florence, SC | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Wilmington Bus Station | Florence, SC | No tags | ||||
| Bus | Delaware Rest Stop S | Florence, SC | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Newark (DE) | Bus station | No tags |
Last refresh of the prices: Yesterday at 12:02 PM EDT.
Compare 2 ways to travel from Wilmington to Florence
Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 10 hours 27 minutes and with fares starting at just CHF 93, it presents an excellent value for a comfortable ride.
Where are the popular stops in Wilmington and Florence?
Stops in Wilmington
- AWilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
- B100 French St, Wilmington, DE 19801, USA
- C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Based on 12512 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained about the Wi-Fi. FlixBus ticket prices on this trip start at CHF 72
Frequently asked questions about travelling from Wilmington, DE to Florence, SC, US by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Wilmington to Florence?
The cheapest bus tickets from Wilmington to Florence start at CHF 61. The average price for this route is around CHF 109. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Wilmington to Florence?
The average bus journey time from Wilmington to Florence is 16h 15m, covering a distance of 712 km. The fastest bus gets you there in 12h 55m and is operated by FlixBus.
Which bus companies service the Wilmington to Florence route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Wilmington to Florence?
The earliest bus departs from Wilmington to Florence at 11:20. And the latest bus departs at 21:25.
What are the CO₂ emissions for the bus trip from Wilmington to Florence?
A bus trip from Wilmington to Florence produces an estimated 17.778875 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on 22 Apr 2026 with a price of CHF 126To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US as early as possible.
What's the cheapest way to go from Wilmington, DE to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
