How far is Wilmington from Florence?

The distance between the two cities is 443 miles (714 km).

What are the departure and arrival stations when taking the bus from Wilmington to Florence?

Most of the buses traveling from Wilmington to Florence leave from Wilmington Bus Station and arrive at Florence Bus Station. These are the primary departure and arrival locations on this route, but you can also find other options that could better fit your plans.

What are the best sights and things to do in Florence?

Once in Florence, you can start exploring the city and discover its surroundings. The top sights and things to do are Basilica di San Lorenzo, Palazzo Vecchio, Basilica Santa Croce, Santa Maria Novella and Galleria dell’Accademia.

Bus Wilmington to Florence from $64 | Refundable Tickets

Previously seen trips

Next departures for Wilmington to Florence on November 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	1:50pm	Wilmington Bus Station	15h 45m	5:35am	Florence, SC	No tags
	Bus	9:25pm	Wilmington Bus Station	15h 20m	12:45pm	Bus station	No tags
	Bus	9:25pm	Wilmington Bus Station	15h 20m	12:45pm	Bus station	No tags
FlixBus + Greyhound	Bus	5:00pm	Wilmington Bus Station	1d 12h	5:35am	Florence, SC	No tags
Greyhound + FlixBus	Bus	5:00pm	Wilmington Bus Station	1d 12h	5:35am	Florence, SC	No tags

Compare 2 ways to go from Wilmington to Florence

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Florence. The journey takes about 10 hours 1 minute and with fares starting at just $113, it presents an excellent value for a comfortable ride.

2train per day

10h 1mAverage Duration

447 milesDistance

66kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$72 - $168	Average Duration16h 15m	CO₂ emissions 18kg CO₂e
Train	Average Price$113 - $356	Average Duration10h 1m	CO₂ emissions 66kg CO₂e

Where are the popular stops in Wilmington and Florence?

Stops in Wilmington

A
Wilmington Bus Station
Wilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA
Visit page
B
Wilmington Station
100 French St, Wilmington, DE 19801, USA
Visit page
C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

FlixBus

3.5/511,386 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,386 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Wilmington, DE to Florence, SC, US by bus

How far is Wilmington from Florence?
What are the departure and arrival stations when taking the bus from Wilmington to Florence?
What are the best sights and things to do in Florence?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/18

No data

11/19

$63

Today

$64

11/21

$83

11/22

No data

11/23

$77

11/24

$81

11/25

$119

The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on Nov 19, 2025 with a price of $63

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US, as early as possible.

You can expect to pay from $63 to $120 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $77 which is on 2025-11-23.