Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus
| Wilmington Bus Station | Bus station | Cheapest | ||||
 | Bus
| Newark (DE) | Florence, SC | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus
| Wilmington Bus Station | Florence, SC | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus
| Wilmington Bus Station | Bus station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus
| Newark (DE) | Bus station | No tags |
Last refresh of the prices: Yesterday at 5:13 PM EDT.
Compare 2 ways to go from Wilmington to Florence
Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 15 hours 55 minutes, and with fares starting at just CLP 58,844, it presents an excellent value for a comfortable ride.
Bus stations and stops in Wilmington and Florence
Stops in Wilmington
- A
Wilmington Bus Station
Wilmington Bus Station, 101 N French St, Wilmington, DE 19801, USA - B
Amtrak/SEPTA Station
100 French St, Wilmington, DE 19801, USA - C
Wilmington Bus Stop
101 N French , Wilmington, DE 19801
Stops in Florence
- A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA - B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling from Wilmington, DE to Florence, SC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Wilmington to Florence?
The cheapest bus tickets from Wilmington to Florence start from CLP 58,844. The average price for this route is around CLP 103,853. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Wilmington to Florence?
The average bus travel time from Wilmington to Florence is 15h 55m, covering a distance of 716 km. The quickest bus can get you there in 11h 4m and is operated by Greyhound.
Which bus companies service the Wilmington to Florence route?
What are the earliest and latest departure times for the bus from Wilmington to Florence?
The earliest bus departs from Wilmington to Florence at 12:55am. And the latest bus departs at 9:45pm.
What are the CO₂ emissions for the bus trip from Wilmington to Florence?
A bus trip from Wilmington to Florence generates an estimated 17.875524999999996 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Wilmington to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88149 reviews.
Which bus company has the best Wi-Fi from Wilmington to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Wilmington to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Wilmington to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on Sep 16, 2026 with a price of CLP 60,635To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US, as early as possible.
What's the cheapest way to go from Wilmington, DE to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
