Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Florence Station | Chicago (Union Station), IL | CheapestFastest | ||||
| Train | Florence Station | Chicago (Union Station), IL | No tags | ||||
| Train | Florence Station | Chicago (Union Station), IL | No tags | ||||
| Train | Florence Station | Chicago (Union Station), IL | No tags |
Last refresh of the prices: Last Wednesday at 8:59 PM EST.
Compare 2 ways to go from Florence to Chicago
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 3 hours 30 minutes and with fares starting at just $124, it presents an excellent value for a comfortable ride.
Train Companies
Based on 5639 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $286
Frequently asked questions about traveling from Florence, SC, US to Chicago by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Florence to Chicago?
The cheapest train tickets from Florence to Chicago start from $286. The average price for this train route is around $467. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Florence to Chicago?
The average train ride duration from Florence to Chicago is 1d 11h, covering a distance of 681 miles (1098 km). The quickest train can get you there in 1d 10h and is operated by Amtrak.
Which train operators service the Florence to Chicago route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the train from Florence to Chicago?
The earliest train departs from Florence to Chicago at 11:32pm. And the latest train departs at 11:32pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Chicago was searched and found on Dec 16, 2025 with a price of $339To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Florence, SC, US to Chicago, as early as possible.
You can expect to pay from $339 to $2,266 for a train ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $339 which is on 2025-12-16.
