Bus Tickets from Florence, SC, US to Chicago

Previously seen trips

Next departures for Florence to Chicago on October 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Bus station
537-517 W. Jackson BlvdNo tags
Greyhound
Bus station
Chicago 95Th & Dan RyanNo tags
Greyhound + FlixBus
Florence, SC
Downtown Greyhound StationNo tags
FlixBus + Greyhound
Florence, SC
Chicago 95Th & Dan RyanNo tags
Greyhound + FlixBus
Florence, SC
537-517 W. Jackson BlvdNo tags

Accepted payments

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Compare 2 ways to go from Florence to Chicago.

Bus
Average Price$93 - $318Average Duration1d 5h
27kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$198 - $481Average Duration1d 11h
100kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Florence to Chicago

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 1 day, 5 hours 5 minutes and with fares starting at just $93, it presents an excellent value for a comfortable ride.

8bus per day
1d 5hAverage Duration
$93Cheapest ticket
27kgCO₂ emissions

Bus Florence, SC, US to Chicago: Trip Overview

Average ticket price$165
Average bus trip duration1d 5h
Number of daily buses8
Earliest bus departure12:05am
Distance673 miles (1084 km)
Latest bus departure4:15pm

Florence to Chicago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Chicago.

We make sure you can find a bus service from Florence to Chicago from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Florence to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Florence, SC, US - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/02
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10/03
$159
Today
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10/05
No data
10/06
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10/07
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10/08
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10/09
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busbud logoThe cheapest trip from Florence, SC, US to Chicago was searched and found on Oct 3, 2025 with a price of $159

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Chicago, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Florence to Chicago that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Florence to Chicago.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Florence, SC, US to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence, SC, US by bus?

Bus from Chicago to Florence, SC, US

You can also go to Chicago by train

Train from Florence, SC, US to Chicago

Why choose Busbud?

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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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