Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
HLB + DB Regio Bayern + alex - Die Länderbahn | Train | Mainz Central Train Station | Hlavní nádraží | Cheapest | ||||
vlexx + DB Fernverkehr | Train | Mainz Central Train Station | Hlavní nádraží | Fastest | ||||
S-Bahn Rhein-Main + DB Fernverkehr + DB Regio Bayern + alex - Die Länderbahn | Train | Mainz Central Train Station | Hlavní nádraží | No tags | ||||
DB Fernverkehr + DB Regio Südost + Ceske Drahy | Train | Mainz Central Train Station | Hlavní nádraží | No tags | ||||
 | Train | Mainz Central Train Station | Hlavní nádraží | No tags |
Last refresh of the prices: Yesterday at 4:24 AM CEST.
Compare 2 ways to go from Mainz to Prague
Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 8 hours 25 minutes and with fares starting at just $47, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Mainz and Prague?
Prague
- A
Hlavní nádraží
300/8 Wilsonova, 110 00 Praha, Czechia - B
Praha hl.n
Prague Main Railway Station, 120 00 Praha-Praha 2, Czechia - C
PRG Airport
Aviatická, 161 08, Praha 6, Czechia - D
Florenc
Křižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic - E
Černý Most
Chlumecká, 198 00 Praha 20, Czech Republic - F
Holešovice
Praha-Holešovice, Partyzánská 1546/26, 170 00 Praha 7-Holešovice, Czechia
Train Companies
Based on 10 reviews, the company was rated 3.8 stars on Busbud. Travelers were especially satisfied with the ticket access and the departure location but often complained with the wifi. Deutsche Bahn ticket prices on this trip start at $109
Frequently asked questions about traveling from Mainz to Prague by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from Mainz to Prague?
The cheapest train tickets from Mainz to Prague start from $55. The average price for this train route is around $164. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the train journey from Mainz to Prague?
The average train ride duration from Mainz to Prague is 9h 8m, covering a distance of 274 miles (442 km). The quickest train can get you there in 8h 42m and is operated by Deutsche Bahn.
Which train operators service the Mainz to Prague route?
Several major train operators operate on this route with 9 trains available per day.
What is the earliest and latest departure time for the train from Mainz to Prague?
The earliest train departs from Mainz to Prague at 6:02am. And the latest train departs at 11:32pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Prague was searched and found on Jun 6, 2026 with a price of $132To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Mainz to Prague, as early as possible.
