Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Viale Toselli (Penny Market) | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags |
Compare 2 ways to go from Siena to Palermo
Among the sustainable travel choices, the carpool stands out as a good way to reach Palermo. The journey takes about 13 hours 30 minutes, and with fares starting at just $88, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$80 - $202 | Average Duration17h 25m | 15kg CO₂e | ||
Carpool | Average Price$88 - $88 | Average Duration13h 30m | 25kg CO₂e |
Where are the popular stops in Siena and Palermo?
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
Compare bus companies
Frequently asked questions about travelling from Siena to Palermo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Siena to Palermo?
The cheapest bus tickets from Siena to Palermo start from $80. The average price for this route is around $110. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Siena to Palermo?
The average bus travel time from Siena to Palermo is 17h 25m, covering a distance of 606 km. The quickest bus can get you there in 16h 5m and is operated by FlixBus.
Which bus companies service the Siena to Palermo route?
What are the earliest and latest departure times for the bus from Siena to Palermo?
The earliest bus departs from Siena to Palermo at 11:55am. And the latest bus departs at 9:00pm.
What are the CO₂ emissions for the bus trip from Siena to Palermo?
A bus trip from Siena to Palermo generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Siena to Palermo?
According to Busbud customers, the highest-rated bus company on this route is Itabus, with an average rating of 3.8 out of 5 stars based on 945 reviews.
Which bus company has the best Wi-Fi from Siena to Palermo?
Based on Busbud reviews, the bus company Itabus has the highest Wi-Fi rating with a score of 3.1.
Which bus company has the best on-time performance from Siena to Palermo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Siena to Palermo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Itabus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Siena to Palermo was searched and found on Dec 2, 2025 with a price of $74To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Palermo, as early as possible.
You can expect to pay from $74 to $98 for a bus ticket from Siena to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at $74 which is on 2025-12-02.
