Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Siena Train Station | Terminal Bus Palermo | Cheapest | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | Fastest | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags |
Last refresh of the prices: Yesterday at 12:52 PM CEST.
Get from Siena to Palermo
The journey takes about 16 hours 15 minutes, and with fares starting at just MAD 608, it presents an excellent value for a comfortable ride.
Bus stations and stops in Siena and Palermo
Stops in Siena
- A
Piazza Gramsci
Piazza Antonio Gramsci, 53100 Siena SI, Italy - B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Stops in Palermo
- A
Terminal Bus Palermo
Via Tommaso Fazello, 16, 90123 Palermo PA, Italy - B
Palermo Airport
Punta Raisi, 90145, Palermo - C
Piazza Cairoli
Piazza Cairoli, 8-14, 90123 Palermo, Italy - D
Fiera
90143 Palermo PA, Italy - E
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy - F
Piazza Ruggero Settimo, 12
Piazza Ruggero Settimo, 12C, 90139 Palermo, Italy
Compare bus companies
Based on 13120 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at MAD 608
Frequently asked questions about travelling from Siena to Palermo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Siena to Palermo?
The cheapest bus tickets from Siena to Palermo start from MAD 608. The average price for this route is around MAD 1,342. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Siena to Palermo?
The average bus travel time from Siena to Palermo is 16h 15m, covering a distance of 606 km. The quickest bus can get you there in 16h and is operated by FlixBus.
Which bus companies service the Siena to Palermo route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Siena to Palermo?
The earliest bus departs from Siena to Palermo at 7:00pm. And the latest bus departs at 10:25pm.
What are the CO₂ emissions for the bus trip from Siena to Palermo?
A bus trip from Siena to Palermo generates an estimated 15.142325 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Siena to Palermo was searched and found on Aug 3, 2026 with a price of MAD 784To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Palermo, as early as possible.
You can expect to pay from MAD 784 to MAD 1,852 for a bus ticket from Siena to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 784 which is on 2026-08-03.
