Find coaches from Siena to Palermo

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Today3 Aug
Tomorrow4 Aug
Tue5 Aug
from US$99
Wed6 Aug
Thu7 Aug
Fri8 Aug
Sat9 Aug
Sun10 Aug

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 5 August at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: 6 August at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: 5 August at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: 6 August at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: MarinoBus + MarinoBus
    MarinoBus + MarinoBus
    Vehicle: BusDuration:
  • Departure time: 5 August at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: 6 August at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: 5 August at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: 6 August at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: 5 August at
    Departure city: Siena
    Departure location: Viale Toselli (Penny Market)
    Arrival time: 6 August at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to travel from Siena to Palermo

Bus
Average priceUS$63 - US$187Average duration19h 35m
15kg CO₂e5 out of 5 stars
Most eco-friendly
Carpool
Average priceUS$62 - US$105Average duration12h 50m
25kg CO₂e4 out of 5 stars
CheapestFastest
busbud logoBusbud recommends carpooling from Siena to Palermo

Among the sustainable travel choices, the carpool stands out as a good way to reach Palermo. The journey takes about 12 hours 50 minutes and with fares starting at just US$62, it presents an excellent value for a comfortable ride.

1carpool per day
12h 50mAverage duration
US$62Cheapest ticket
25kgCO₂ emissions

Bus Siena to Palermo: Trip Overview

Average ticket priceUS$133
Average bus trip duration19h 35m
Number of daily buses6
Earliest bus departure11:35
Distance376 miles
Latest bus departure21:20

Siena to Palermo Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Siena to Palermo.

We make sure you can find a bus service from Siena to Palermo from the most reliable bus companies operating this trip.

Discover how much the bus trip from Siena to Palermo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Siena - Palermo

  1. What's the distance between Siena and Palermo by coach?

    The distance between Siena and Palermo by coach is approximately 375 miles (604 km).

  2. How can I travel from Siena to Palermo avoiding air travel?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/08
US$82
02/08
No data
Today
No data
04/08
No data
05/08
US$95
06/08
No data
07/08
No data
08/08
No data
busbud logoThe cheapest trip from Siena to Palermo was searched and found on 1 Aug 2025 with a price of US$82

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Palermo as early as possible.

You can expect to pay from US$82 to US$167 for a bus ticket from Siena to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at US$95, which is on 2025-08-05.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Siena to Palermo but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Siena to Palermo, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Siena to Palermo will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Siena to Palermo.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Siena by bus?

Bus from Siena to Palermo

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