Train from Chicago to Florence, SC, US: Tickets & Schedules

Previously seen trips

Next departures for Chicago to Florence on February 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags

Compare 2 ways to go from Chicago to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 2 hours 30 minutes, and with fares starting at just $150, it presents an excellent value for a comfortable ride.

10bus per day
1d 2hAverage Duration
1098 kmDistance
27kgCO₂ emissions
Average Price$150 - $403Average Duration1d 2h
27kg CO₂e
Average Price$303 - $716Average Duration1d 7h
100kg CO₂e

Frequently asked questions about travelling from Chicago to Florence, SC, US by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the train ticket from Chicago to Florence?

    The cheapest train tickets from Chicago to Florence start at $303. The average price for this train route is around $481. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.

  2. How long is the train ride from Chicago to Florence?

    The average train trip from Chicago to Florence takes 1d 7h and covers 1098 km. The quickest train gets you there in 1d 7h and is operated by Amtrak.

  3. Which train operators serve the Chicago to Florence route?

    Several major train operators serve this route, with 1 trains available per day.

  4. What are the earliest and latest departure times for the train from Chicago to Florence?

    The earliest train from Chicago to Florence departs at 6:40pm. The latest train departs at 6:40pm.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01-30
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01-31
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Today
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02-02
$385
02-03
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02-04
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02-05
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busbud logoThe cheapest trip from Chicago to Florence, SC, US was searched and found on Feb 2, 2026 with a price of $385

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Chicago to Florence, SC, US, as early as possible.

You can expect to pay from $385 to $1,566 for a train ticket from Chicago to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $385 which is on 2026-02-02.

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