Train from Chicago to Florence, SC, US: Tickets & Schedules

Previously seen trips

Next departures for Chicago to Florence on February 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags
AmtrakTrain
Chicago (Union Station), IL
Florence StationNo tags

Compare 2 ways to go from Chicago to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 2 hours 30 minutes and with fares starting at just $108, it presents an excellent value for a comfortable ride.

10bus per day
1d 2hAverage Duration
681 milesDistance
27kgCO₂ emissions
Average Price$108 - $289Average Duration1d 2h
27kg CO₂e
Average Price$217 - $512Average Duration1d 7h
100kg CO₂e

Frequently asked questions about traveling from Chicago to Florence, SC, US by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the train ticket from Chicago to Florence?

    The cheapest train tickets from Chicago to Florence start from $217. The average price for this train route is around $344. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the train journey from Chicago to Florence?

    The average train ride duration from Chicago to Florence is 1d 7h, covering a distance of 681 miles (1098 km). The quickest train can get you there in 1d 7h and is operated by Amtrak.

  3. Which train operators service the Chicago to Florence route?

    Several major train operators operate on this route with 1 trains available per day.

  4. What is the earliest and latest departure time for the train from Chicago to Florence?

    The earliest train departs from Chicago to Florence at 6:40pm. And the latest train departs at 6:40pm.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/30
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01/31
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Today
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02/02
$275
02/03
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02/04
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02/05
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02/06
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busbud logoThe cheapest trip from Chicago to Florence, SC, US was searched and found on Feb 2, 2026 with a price of $275

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Chicago to Florence, SC, US, as early as possible.

You can expect to pay from $275 to $1,120 for a train ticket from Chicago to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $275 which is on 2026-02-02.

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