Previously seen trips

Next departures for Chicago to Florence on October 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location
Greyhound + FlixBus	Bus Wi‑Fi Toilet Power outlets	6:40pm	Chicago 95Th & Dan Ryan	1d 4h	12:05am	Florence, SC
FlixBus + Greyhound	Bus Wi‑Fi Toilet Power outlets	9:40pm	Downtown Greyhound Station	1d 7h	5:45am	Florence, SC
Greyhound + FlixBus	Bus Wi‑Fi Toilet Power outlets	10:00pm	537-517 W. Jackson Blvd	1d 6h	5:45am	Florence, SC
FlixBus + Greyhound	Bus Wi‑Fi Toilet Power outlets	10:30pm	Chicago 95Th & Dan Ryan	1d 6h	5:45am	Florence, SC
Greyhound + FlixBus	Bus Wi‑Fi Toilet Power outlets	6:40pm	Chicago 95Th & Dan Ryan	1d 4h	12:05am	Florence, SC

Compare 2 ways to go from Chicago to Florence

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Florence. The journey takes about 1 day, 2 hours 15 minutes, and with fares starting at just $124, it presents an excellent value for a comfortable ride.

9bus per day

1d 2hAverage Duration

1092 kmDistance

27kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$124 - $384	Average Duration1d 2h	CO₂ emissions 27kg CO₂e
Train	Average Price$483 - $541	Average Duration1d 7h	CO₂ emissions 100kg CO₂e

Bus stations and stops in Chicago and Florence

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Compare bus companies

Greyhound

3.5/588,240 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/516,291 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about travelling from Chicago to Florence, SC, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Chicago to Florence?
The cheapest bus tickets from Chicago to Florence start from $124. The average price for this route is around $181. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Florence?
The average bus travel time from Chicago to Florence is 1d 2h, covering a distance of 1092 km. The quickest bus can get you there in 1d 2h and is operated by Greyhound.
Which bus companies service the Chicago to Florence route?
Several major bus companies operate on this route with 9 buses available per day, including services from Greyhound, FlixBus.
What are the earliest and latest departure times for the bus from Chicago to Florence?
The earliest bus departs from Chicago to Florence at 5:15am. And the latest bus departs at 11:55pm.
What are the CO₂ emissions for the bus trip from Chicago to Florence?
A bus trip from Chicago to Florence generates an estimated 27.2802 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to Florence?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88213 reviews.
Which bus company has the best Wi-Fi from Chicago to Florence?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

10-16

$192

10-17

$182

Today

$172

10-19

No data

10-20

$162

10-21

$157

10-22

No data

10-23

$178

The cheapest trip from Chicago to Florence, SC, US was searched and found on Oct 21, 2026 with a price of $157

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Florence, SC, US, as early as possible.

You can expect to pay from $157 to $203 for a bus ticket from Chicago to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $157 which is on 2026-10-21.