Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Santa Fe Depot | Greyhound Amtrak Station | Cheapest | |||||
| Old Town San Diego | Greyhound Amtrak Station | Fastest | |||||
| Santa Fe Depot | Greyhound Amtrak Station | No tags | |||||
| Santa Fe Depot | Greyhound Amtrak Station | No tags | |||||
| Santa Fe Depot | Greyhound Amtrak Station | No tags |
Last refresh of the prices: Yesterday at 7:00 PM PST.
Compare 2 ways to go from San Diego to Indianapolis
Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 2 days, 6 hours 55 minutes, and with fares starting at just $406, it presents an excellent value for a comfortable ride.
Train companies
Based on 5666 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $435
Frequently asked questions about travelling from San Diego, CA, US to Indianapolis by train
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the train ticket from San Diego to Indianapolis?
The cheapest train tickets from San Diego to Indianapolis start at $559. The average price for this train route is around $2,089. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.
How long is the train ride from San Diego to Indianapolis?
The average train trip from San Diego to Indianapolis takes 2d 6h and covers 2874 km. The quickest train gets you there in 2d 6h and is operated by Amtrak.
Which train operators serve the San Diego to Indianapolis route?
Several major train operators serve this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from San Diego to Indianapolis?
The earliest train from San Diego to Indianapolis departs at 2:01pm. The latest train departs at 4:10pm.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Dec 23, 2025 with a price of $612To save money and be sure you have the best seat, it's a good idea to buy your train tickets from San Diego, CA, US to Indianapolis, as early as possible.
You can expect to pay from $612 to $3,781 for a train ticket from San Diego, CA, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $612 which is on 2025-12-23.
