Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Greyhound Bus Stop | Downtown Transit Center | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UCSD Health La Jolla Station | Indianapolis Bus Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Indianapolis Bus Station | No tags | ||||
 | Bus | Greyhound Bus Stop | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Diego (Old Town-FlixBus) | Indianapolis Bus Station | No tags |
Last refresh of the prices: Yesterday at 7:00 PM PST.
Compare 2 ways to go from San Diego to Indianapolis
Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 2 days, 6 hours 55 minutes, and with fares starting at just $406, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Indianapolis?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from San Diego, CA, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Indianapolis?
The cheapest bus tickets from San Diego to Indianapolis start from $406. The average price for this route is around $619. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Indianapolis?
The average bus travel time from San Diego to Indianapolis is 2d 6h, covering a distance of 2871 km. The quickest bus can get you there in 2d 1h and is operated by FlixBus.
Which bus companies service the San Diego to Indianapolis route?
What are the earliest and latest departure times for the bus from San Diego to Indianapolis?
The earliest bus departs from San Diego to Indianapolis at 6:45am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to Indianapolis?
A bus trip from San Diego to Indianapolis generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from San Diego to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from San Diego to Indianapolis?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from San Diego to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Dec 24, 2025 with a price of $477To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis, as early as possible.
You can expect to pay from $477 to $1,012 for a bus ticket from San Diego, CA, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $477 which is on 2025-12-24.
What's the cheapest way to go from San Diego, CA, US to Indianapolis?
The bus is the cheapest travel choice for this destination
