Bus from San Diego, CA, US to Indianapolis: Tickets & Schedules
Next bus departures
Next departures for San Diego to Indianapolis on January 13
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Greyhound Bus Stop
Indianapolis Bus Station
CheapestFastest
Greyhound Lines, Inc. + FlixBus
Bus
Greyhound Bus Stop
Downtown Transit Center
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Greyhound Bus Stop
Indianapolis Northeast
No tags
Next departures for San Diego to Indianapolis on January 14
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
UCSD Health La Jolla Station
Indianapolis Bus Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Bus
Greyhound Bus Stop
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Downtown Transit Center
No tags
Next departures for San Diego to Indianapolis on January 15
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Greyhound Bus Stop
Indianapolis Northeast
Cheapest
Bus
Greyhound Bus Stop
Indianapolis Bus Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Bus
Greyhound Bus Stop
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Next departures for San Diego to Indianapolis on January 16
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Greyhound Bus Stop
Downtown Transit Center
Cheapest
Bus
Greyhound Bus Stop
Indianapolis Bus Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Bus
Greyhound Bus Stop
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Next departures for San Diego to Indianapolis on January 17
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Greyhound Bus Stop
Indianapolis Bus Station
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Bus
Greyhound Bus Stop
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Next departures for San Diego to Indianapolis on January 18
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
Cheapest
Bus
Greyhound Bus Stop
Indianapolis Bus Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Bus
Greyhound Bus Stop
Indianapolis Bus Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
San Diego (Old Town-FlixBus)
Indianapolis Bus Station
No tags
Last refresh of the prices: Last Thursday at 3:12 PM PST.
Compare 2 ways to go from San Diego to Indianapolis
We recommend taking the bus
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 2 days, 8 hours 5 minutes, and with fares starting at just $230, it presents an excellent value for a comfortable ride.
Based on 87499 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $233
Based on 5731 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $473
Based on 12034 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. FlixBus ticket prices on this trip start at $164
Frequently asked questions about travelling from San Diego, CA, US to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Diego to Indianapolis?
The cheapest bus tickets from San Diego to Indianapolis start from $230. The average price for this route is around $495. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Indianapolis?
The average bus travel time from San Diego to Indianapolis is 2d 8h, covering a distance of 2871 km. The quickest bus can get you there in 2d 1h and is operated by FlixBus.
Which bus companies service the San Diego to Indianapolis route?
Several major bus companies operate on this route with 23 buses available per day, including services from Greyhound, Amtrak, FlixBus.
What are the earliest and latest departure times for the bus from San Diego to Indianapolis?
The earliest bus departs from San Diego to Indianapolis at 6:45am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to Indianapolis?
A bus trip from San Diego to Indianapolis generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from San Diego to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which bus company has the best Wi-Fi from San Diego to Indianapolis?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from San Diego to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
01-11
$577
01-12
$371
Today
$431
01-14
$448
01-15
$420
01-16
$437
01-17
$399
01-18
$396
The cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Jan 12, 2026 with a price of $371
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis, as early as possible.
You can expect to pay from $371 to $577 for a bus ticket from San Diego, CA, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $396 which is on 2026-01-18.
What's the cheapest way to go from San Diego, CA, US to Indianapolis?
The Bus is the cheapest travel choice for this destination
The cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Jan 12, 2026 with a price of $371
The Bus is the cheapest travel choice for this destination
