Bus Tickets from San Diego, CA, US to Indianapolis

Previously seen trips

Next departures for San Diego to Indianapolis on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
San Diego (Old Town-FlixBus)
Indianapolis Bus StationNo tags
FlixBus + Greyhound
UCSD Health La Jolla Station
Downtown Transit CenterNo tags
Greyhound + FlixBus
UCSD Health La Jolla Station
Indianapolis Bus StationNo tags
FlixBus + Greyhound
Greyhound Bus Stop
Downtown Transit CenterNo tags
Greyhound
Greyhound Bus Stop
Indianapolis Bus StationNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus San Diego, CA, US to Indianapolis: Trip Overview

Average Ticket PriceUS$201
Average Bus Trip Duration2d 8h
Number of daily buses17
Earliest bus departure6:45am
Distance2874 km
Latest bus departure7:35pm

San Diego to Indianapolis Bus

Busbud helps you find a bus from San Diego to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Diego to Indianapolis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - Indianapolis

  1. How far is San Diego from Indianapolis?

    The distance covered from San Diego to Indianapolis is 2876 km (1783 miles).

  2. What are the departure and arrival locations for buses traveling from San Diego to Indianapolis?

    Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Greyhound Amtrak Station, in Indianapolis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-04
US$307
10-05
No data
Today
No data
10-07
No data
10-08
US$192
10-09
US$204
10-10
No data
10-11
No data
busbud logoThe cheapest trip from San Diego, CA, US to Indianapolis was searched and found on Oct 8, 2025 with a price of US$192

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Indianapolis, as early as possible.

You can expect to pay from US$192 to US$436 for a bus ticket from San Diego, CA, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$192 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Indianapolis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to San Diego, CA, US by bus?

Bus from Indianapolis to San Diego, CA, US

You can also go to Indianapolis by train

Train from San Diego, CA, US to Indianapolis

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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