Train from Greenville, SC to Chicago: Tickets & Schedules

Previously seen trips

Next departures for Greenville to Chicago on November 29
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags
AmtrakTrain
Greenville Station
Chicago (Union Station), ILNo tags

Compare 2 ways to go from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes, and with fares starting at just $117, it presents an excellent value for a comfortable ride.

14bus per day
21h 30mAverage Duration
911 kmDistance
23kgCO₂ emissions
Average Price$117 - $587Average Duration21h 30m
23kg CO₂e
Average Price$253 - $2,916Average Duration1d 7h
82kg CO₂e

Frequently asked questions about travelling from Greenville, SC to Chicago by train

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the train ticket from Greenville to Chicago?

    The cheapest train tickets from Greenville to Chicago start at $253. The average price for this train route is around $438. Busbud recommends booking your tickets in advance to increase your chances of getting the lowest possible price.

  2. How long is the train ride from Greenville to Chicago?

    The average train trip from Greenville to Chicago takes 1d 7h and covers 904 km. The quickest train gets you there in 1d 7h and is operated by Amtrak.

  3. Which train operators serve the Greenville to Chicago route?

    Several major train operators serve this route, with 1 trains available per day.

  4. What are the earliest and latest departure times for the train from Greenville to Chicago?

    The earliest train from Greenville to Chicago departs at 2:23am. The latest train departs at 2:23am.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-26
$496
11-27
No data
Today
$578
11-29
No data
11-30
No data
12-01
No data
12-02
No data
12-03
No data
busbud logoThe cheapest trip from Greenville, SC to Chicago was searched and found on Nov 26, 2025 with a price of $496

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Greenville, SC to Chicago, as early as possible.

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