Bus Tickets from Greenville, SC to Chicago

Next departures

Next departures for Greenville to Chicago on November 9
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		1116 Woodruff Rd
    		Chicago 95Th & Dan RyanCheapest
    FlixBus + Greyhound Lines, Inc.
      		1116 Woodruff Rd
      		Downtown Greyhound StationFastest
      FlixBus
        		1116 Woodruff Rd
        		Downtown Greyhound StationNo tags
        FlixBus + Greyhound Lines, Inc.
          		1116 Woodruff Rd
          		537-517 W. Jackson BlvdNo tags
          FlixBus
            		1116 Woodruff Rd
            		Chicago 95Th & Dan RyanNo tags

            Last refresh of the prices: Yesterday at 2:06 PM EST.

            Compare 2 ways to go from Greenville to Chicago

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 21 hours 25 minutes, and with fares starting at just $112, it presents an excellent value for a comfortable ride.

            12bus per day
            21h 25mAverage Duration
            911 kmDistance
            23kgCO₂ emissions
            Bus
            		Average Price$112 - $423Average Duration21h 25m
            23kg CO₂e
            Train
            		Average Price$254 - $3,065Average Duration1d 7h
            82kg CO₂e

            Frequently asked questions about travelling from Greenville, SC to Chicago by bus

            1. What is the distance between Greenville and Chicago?

              The distance between Greenville and Chicago is around 904 km (561 miles).

            2. What are the departure and arrival locations for buses traveling from Greenville to Chicago?

              Buses traveling this route start their trip at Guadalajara Supermarket Bus Stop, in Greenville, and end it at Downtown Greyhound Station, in Chicago.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            11-07
            $250
            11-08
            $229
            Today
            $233
            11-10
            $152
            11-11
            No data
            11-12
            No data
            11-13
            $139
            11-14
            No data
            busbud logoThe cheapest trip from Greenville, SC to Chicago was searched and found on Nov 13, 2025 with a price of $139

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.

            You can expect to pay from $139 to $294 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $139 which is on 2025-11-13.

            What's the cheapest way to go from Greenville, SC to Chicago?

            busbud logoThe bus is the cheapest travel choice for this destination

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