Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Chicago 95Th & Dan Ryan | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | 537-517 W. Jackson Blvd | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 1116 Woodruff Rd | Downtown Greyhound Station | No tags | ||||
 | Bus | 1116 Woodruff Rd | Downtown Greyhound Station | No tags | ||||
 | Bus | 1116 Woodruff Rd | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Today at 8:51 AM EST.
Compare 2 ways to go from Greenville to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes, and with fares starting at just $130, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Chicago?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Greenville, SC to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Chicago?
The cheapest bus tickets from Greenville to Chicago start from $130. The average price for this route is around $205. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Chicago?
The average bus travel time from Greenville to Chicago is 21h 30m, covering a distance of 896 km. The quickest bus can get you there in 20h 45m and is operated by Greyhound.
Which bus companies service the Greenville to Chicago route?
What are the earliest and latest departure times for the bus from Greenville to Chicago?
The earliest bus departs from Greenville to Chicago at 12:15pm. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Chicago?
A bus trip from Greenville to Chicago generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Chicago?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11828 reviews.
Which bus company has the best Wi-Fi from Greenville to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Greenville to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Chicago was searched and found on Jan 10, 2026 with a price of $169To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.
You can expect to pay from $169 to $258 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $169 which is on 2026-01-10.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Greenville, SC to Chicago?
The Bus is the cheapest travel choice for this destination
