Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags | ||||
| Train | Gateway Station | Depew Station | No tags |
Compare 2 ways to go from St. Louis to Buffalo
Among the sustainable travel choices, the bus stands out as a good way to reach Buffalo. The journey takes about 1 day, 8 hours 45 minutes, and with fares starting at just $182, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in St. Louis and Buffalo, NY?
Train companies
Based on 5607 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $207
Frequently asked questions about travelling from St. Louis to Buffalo, NY by train
How much does a cheap train ticket from St. Louis to Buffalo cost?
The average train ticket price from St. Louis to Buffalo is $425. The best way to find cheap train tickets from St. Louis to Buffalo is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the trip from St. Louis to Buffalo?
A train trip between St. Louis and Buffalo is around 16h 58m, although the fastest train will take about 16h 58m. This is the time it takes to travel the 1065 km that separates the two cities.
How many daily trains are there between St. Louis and Buffalo?
The number of trains from St. Louis to Buffalo can differ depending on the day of the week. On average, there are 2. Some trains are direct while others include transferring trains. Simplify your train trip from St. Louis to Buffalo by comparing and selecting the train that fits your travel style and budget on Busbud.
Which train companies travel from St. Louis to Buffalo?
When taking the train from St. Louis to Buffalo, you can travel comfortably and safely with Amtrak.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Buffalo, NY was searched and found on Nov 25, 2025 with a price of $409To save money and be sure you have the best seat, it's a good idea to buy your train tickets from St. Louis to Buffalo, NY, as early as possible.
You can expect to pay from $409 to $1,343 for a train ticket from St. Louis to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $409 which is on 2025-11-28.
