Next bus departures

Next departures from Florence to Chicago on 9 October
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	18:35	Bus station	1d 6h	23:55	Chicago 95Th & Dan Ryan	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	12:05	Bus station	1d	11:05	Chicago 95Th & Dan Ryan	Fastest
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	12:05	Bus station	1d	11:30	Downtown Greyhound Station	No tags
	Bus Wi‑Fi Toilet Power outlets	14:55	Bus station	1d 1h	15:15	Downtown Greyhound Station	No tags
	Bus Wi‑Fi Toilet Power outlets	15:20	Bus station	1d 5h	20:10	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	18:35	Bus station	1d 6h	00:10	Downtown Greyhound Station	No tags
	Bus Wi‑Fi Toilet Power outlets	12:05	Bus station	1d 2h	13:45	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus Wi‑Fi Toilet Power outlets	14:55	Bus station	1d 4h	18:25	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Yesterday at 19:02 EDT.

Compare 2 ways to travel from Florence to Chicago

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours 5 minutes and with fares starting at just COP 274,652, it presents an excellent value for a comfortable ride.

14bus per day

1d 5hAverage duration

1093 kmDistance

27kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceCOP 274,652 - COP 1,797,341	Average duration1d 5h	CO₂ emissions 27kg CO₂e
Train	Average priceCOP 800,569 - COP 5,785,024	Average duration1d 12h	CO₂ emissions 100kg CO₂e

Bus stations and stops in Florence and Chicago

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/588,214 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/516,135 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wi‑Fi2.7

US bus companies:FlixBus, Greyhound, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit, Wanda Coach

Frequently asked questions about travelling by bus from Florence, SC, US to Chicago

Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.

How much is the bus ticket from Florence to Chicago?
The cheapest coach tickets from Florence to Chicago start from COP 274,652. The average price for this route is around COP 446,379. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Florence to Chicago?
The average bus journey time from Florence to Chicago is 1d 5h, covering a distance of 1093 km. The fastest bus can take you there in 1d 1h and is operated by Greyhound.
Which bus companies service the Florence to Chicago route?
Several major bus companies operate on this route with 14 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Florence to Chicago?
The earliest bus departs from Florence to Chicago at 00:05. And the latest bus departs at 19:20.
What are the CO₂ emissions for the bus trip from Florence to Chicago?
A bus journey from Florence to Chicago produces an estimated 27.307675 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Florence to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88207 reviews.
Which company has the best Wi-Fi from Florence to Chicago?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Florence to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

07/10

COP 495,397

08/10

COP 535,034

Today

COP 710,032

10/10

COP 455,760

11/10

No data

12/10

COP 326,874

13/10

COP 359,971

14/10

COP 325,288

The cheapest trip from Florence, SC, US to Chicago was searched and found on 14 Oct 2026 with a price of COP 325,288

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago as early as possible.

You can expect to pay from COP 325,288 to COP 974,345 for a bus ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at COP 325,288, which is on 2026-10-14.