Previously seen trips

Next departures for Florence to Chicago on September 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location
Greyhound + FlixBus	Bus Wi‑Fi Toilet Power outlets	5:45am	Florence, SC	1d 5h	9:50am	Chicago 95Th & Dan Ryan
Greyhound + FlixBus	Bus Wi‑Fi Toilet Power outlets	5:45am	Florence, SC	1d 3h	8:15am	Downtown Greyhound Station
FlixBus + Greyhound	Bus Wi‑Fi Toilet Power outlets	5:45am	Florence, SC	1d 3h	8:15am	Downtown Greyhound Station
FlixBus + Greyhound	Bus Wi‑Fi Toilet Power outlets	5:45am	Florence, SC	1d 5h	9:50am	Chicago 95Th & Dan Ryan
	Bus Wi‑Fi Toilet Power outlets	12:55pm	Bus station	1d 4h	3:55pm	Chicago 95Th & Dan Ryan

Compare 2 ways to go from Florence to Chicago

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours 5 minutes, and with fares starting at just ₪260, it presents an excellent value for a comfortable ride.

12bus per day

1d 5hAverage Duration

1093 kmDistance

27kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price₪260 - ₪1,701	Average Duration1d 5h	CO₂ emissions 27kg CO₂e
Train	Average Price₪787 - ₪5,472	Average Duration1d 12h	CO₂ emissions 100kg CO₂e

Bus stations and stops in Florence and Chicago

Stops in Florence

A
Florence Bus Station
619 S Irby St, Florence, SC 29501, USA
Visit page
B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/588,175 reviews

Staff3.6

Timeliness3.0

Cleanliness3.4

Wi‑Fi2.5

FlixBus

3.5/515,890 reviews

Staff4.2

Timeliness4.0

Cleanliness4.1

Wi‑Fi2.7

US bus companies:FlixBus, Greyhound, Futura, Tufesa, Chihuahuenses, Adirondack Trailways, Valley Transit

Frequently asked questions about travelling from Florence, SC, US to Chicago by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Florence to Chicago?
The cheapest bus tickets from Florence to Chicago start from ₪260. The average price for this route is around ₪429. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Chicago?
The average bus travel time from Florence to Chicago is 1d 5h, covering a distance of 1093 km. The quickest bus can get you there in 1d 1h and is operated by Greyhound.
Which bus companies service the Florence to Chicago route?
Several major bus companies operate on this route with 12 buses available per day, including services from Greyhound, FlixBus.
What are the earliest and latest departure times for the bus from Florence to Chicago?
The earliest bus departs from Florence to Chicago at 12:05am. And the latest bus departs at 7:20pm.
What are the CO₂ emissions for the bus trip from Florence to Chicago?
A bus trip from Florence to Chicago generates an estimated 27.311649999999997 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Florence to Chicago?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 88149 reviews.
Which bus company has the best Wi-Fi from Florence to Chicago?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Florence to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Florence to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

09-24

₪347

09-25

₪375

Today

No data

09-27

No data

09-28

No data

09-29

₪327

09-30

No data

10-01

₪353

The cheapest trip from Florence, SC, US to Chicago was searched and found on Sep 29, 2026 with a price of ₪327

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.

You can expect to pay from ₪327 to ₪450 for a bus ticket from Florence, SC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at ₪327 which is on 2026-09-29.