Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Bus station | Downtown Greyhound Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Yesterday at 7:20 PM EST.
Compare 2 ways to go from Florence to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 4 hours 55 minutes, and with fares starting at just $178, it presents an excellent value for a comfortable ride.
8bus per day
1d 4hAverage Duration
1084 kmDistance
27kgCO₂ emissions
Compare bus companies
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Where are the popular stops in Florence and Chicago?
Stops in Florence
Stops in Chicago
Frequently asked questions about travelling from Florence, SC, US to Chicago by bus
How far is Florence from Chicago?
The distance between Florence and Chicago is around 1102 km (684 miles).
What are the departure and arrival locations for buses traveling from Florence to Chicago?
Buses traveling this route start their trip at Florence Bus Station, in Florence, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-18
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11-19
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Today
$339
11-21
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11-22
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11-23
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11-24
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11-25
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The cheapest trip from Florence, SC, US to Chicago was searched and found on Nov 20, 2025 with a price of $339To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago, as early as possible.
What's the cheapest way to go from Florence, SC, US to Chicago?
The bus is the cheapest travel choice for this destination
