Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Bus station | Downtown Greyhound Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | Downtown Greyhound Station | No tags | ||||
| Bus | Bus station | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Yesterday at 09:43 EST.
Compare 2 ways to travel from Florence to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 4 hours 55 minutes and with fares starting at just £97, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Chicago?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling by bus from Florence, SC, US to Chicago
What's the distance between Florence and Chicago by coach?
The distance between Florence and Chicago by coach is approximately 684 miles (1102 km).
How can I travel from Florence to Chicago avoiding air travel?
You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Chicago was searched and found on 21 Nov 2025 with a price of £181To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Chicago as early as possible.
What's the cheapest way to go from Florence, SC, US to Chicago?
The bus is the cheapest travel choice for this destination
