Bus from Brussels to Prague: Tickets & Timetables

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Next bus departures

Next departures from Brussels to Prague on 24 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
RegioJetBus
  • Toilet
  • Power outlets
Brussels South (Gare du Midi)
FlorencCheapestFastest

Last refresh of the prices: Yesterday at 4:33 PM CEST.

Compare 2 ways to travel from Brussels to Prague

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Prague. The journey takes about 18 hours 40 minutes and with fares starting at just MAD 251, it presents an excellent value for a comfortable ride.

33bus per day
18h 40mAverage duration
713 kmDistance
18kgCO₂ emissions
Bus
Average priceMAD 251 - MAD 2 043Average duration18h 40m
18kg CO₂e
Train
Average priceMAD 1 164 - MAD 2 479Average duration16h 48m
17kg CO₂e

Frequently asked questions about travelling from Brussels to Prague by bus

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

  1. How much is the bus ticket from Brussels to Prague?

    The cheapest bus tickets from Brussels to Prague start at MAD 251. The average price for this route is around MAD 686. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

  2. How long is the bus journey from Brussels to Prague?

    The average bus journey time from Brussels to Prague is 18h 40m, covering a distance of 713 km. The fastest bus gets you there in 11h 55m and is operated by RegioJet.

  3. Which bus companies service the Brussels to Prague route?

    Several major bus companies operate on this route with 33 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.

  4. What is the earliest and latest departure time for the bus from Brussels to Prague?

    The earliest bus departs from Brussels to Prague at 00:45. And the latest bus departs at 22:55.

  5. What are the CO₂ emissions for the bus trip from Brussels to Prague?

    A bus trip from Brussels to Prague produces an estimated 17.813599999999997 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

  6. What is the best bus company from Brussels to Prague?

    According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1112 reviews.

  7. Which bus company has the best Wi-Fi from Brussels to Prague?

    Based on reviews on Busbud, the bus company RegioJet has the best Wi-Fi rating with a score of 3.7.

  8. Which bus company offers the most punctual service from Brussels to Prague?

    According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 4.0 out of 5 stars.

  9. Which bus company has the cleanest buses from Brussels to Prague?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
20/09
MAD 657
21/09
MAD 968
Today
MAD 254
23/09
No data
24/09
MAD 575
25/09
MAD 392
26/09
No data
27/09
MAD 500
busbud logoThe cheapest trip from Brussels to Prague was searched and found on 22 Sept 2026 with a price of MAD 254

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Prague as early as possible.

You can expect to pay from MAD 254 to MAD 1 475 for a bus ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at MAD 392, which is on 2026-09-25.

What's the cheapest way to go from Brussels to Prague?

busbud logoThe Bus is the cheapest travel choice for this destination

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