Next departures for Brussels to Prague on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Florenc
CheapestFastest
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Main Railway Station)
No tags
Bus
Brussels North Train Station
Prague (Main Station - parking)
No tags
Next departures for Brussels to Prague on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
Cheapest
Bus
Brussels North Train Station
Prague (Na Knížecí)
Fastest
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Next departures for Brussels to Prague on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels South (Gare du Midi)
Florenc
CheapestFastest
Next departures for Brussels to Prague on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels-South (Gare du Midi)
Florenc
CheapestFastest
Next departures for Brussels to Prague on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Holešovice
Cheapest
Bus
Brussels South (Gare du Midi)
Florenc
Fastest
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Next departures for Brussels to Prague on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Brussels North Train Station
Prague (Main Railway Station)
Cheapest
Bus
Brussels-South (Gare du Midi)
Florenc
Fastest
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Bus
Brussels North Train Station
Prague (Central Bus Station Florenc)
No tags
Last refresh of the prices: Today at 2:25 PM CET.
Compare 2 ways to go from Brussels to Prague
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Prague. The journey takes about 19 hours 15 minutes and with fares starting at just $44, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11144 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $49
Based on 1057 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the departure location and the value for money but often complained with the wifi. RegioJet ticket prices on this trip start at $44
RegioJet Brussels Prague recent customer reviews
RegioJet is the best bus
Every Thing was nice
Very good
Musil Tour offers 1 daily departures, and you can find tickets starting at $86. The quickest ride takes around 1060. Musil Tour offers a cost-effective solution to get you where you need to be.
Frequently asked questions about traveling from Brussels to Prague by bus
What is the travel distance from Brussels to Prague?
About 446 miles (719 km) separate Brussels and Prague.
What are the departure and arrival stations when taking the bus from Brussels to Prague?
The majority of buses traveling from Brussels to Prague start their journey at Brussels South (Gare du Midi) and wind up at PRG Airport. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Prague?
Once in Prague, you can start exploring the city and discover its surroundings. The top sights and things to do are Old Wastewater Treatment Plant, Prague Castle and St. Vitus’ Cathedral, Casino, Bungee Jumping and Staronová Synagoga (Old-New Synagogue).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
No data
11/20
$60
Today
$58
11/22
$48
11/23
$59
11/24
$78
11/25
No data
11/26
No data
The cheapest trip from Brussels to Prague was searched and found on Nov 22, 2025 with a price of $48
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Brussels to Prague, as early as possible.
You can expect to pay from $48 to $202 for a bus ticket from Brussels to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $48 which is on 2025-11-22.
What's the cheapest way to go from Brussels to Prague?
The bus is the cheapest travel choice for this destination
The cheapest trip from Brussels to Prague was searched and found on Nov 22, 2025 with a price of $48
The bus is the cheapest travel choice for this destination
