Find coaches from Chicago to Greenville, SC

Previously seen journeys

Next departures from Chicago to Greenville on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Downtown Greyhound Station
1116 Woodruff RdNo tags
FlixBus
Chicago 95Th & Dan Ryan
1116 Woodruff RdNo tags
FlixBus + Greyhound
Downtown Greyhound Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
Downtown Greyhound Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
537-517 W. Jackson Blvd
1116 Woodruff RdNo tags

Accepted payments

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  • American Express
  • China Union Pay
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  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to travel from Chicago to Greenville

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 40 minutes and with fares starting at just US$89, it presents an excellent value for a comfortable ride.

13bus per day
20h 40mAverage duration
896 kmDistance
22kgCO₂ emissions
Bus
Average priceUS$89 - US$341Average duration20h 40m
22kg CO₂e
Train
Average priceUS$255 - US$1 264Average duration1d 9h
82kg CO₂e

Bus Chicago to Greenville, SC: Trip Overview

Average ticket priceUS$139
Average bus trip duration20h 40m
Number of daily buses13
Earliest bus departure00:30
Distance896 km
Latest bus departure23:59

Chicago to Greenville Bus

Busbud helps you find a bus from Chicago to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Chicago to Greenville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Chicago to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Chicago - Greenville, SC

  1. How much does a bus ticket from Chicago to Greenville cost?

    The bus ticket price from Chicago to Greenville starts at US$89. The best way to find cheap bus tickets from Chicago to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Chicago to Greenville?

    The average travel time between Chicago and Greenville is around 20h 40m, although the fastest bus will take about 18h 50m. This is the time it takes to travel the 904 km that separates the two cities.

  3. How many daily bus connections are there between Chicago and Greenville?

    The number of buses from Chicago to Greenville can differ depending on the day of the week. On average, there are 13 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Chicago to Greenville?

    When taking the bus from Chicago to Greenville, you can travel comfortably and safely with FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Chicago to Greenville?

    Buses travelling between Chicago and Greenville leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Guadalajara Supermarket Bus Stop, Greenville Bus Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$95
29/10
US$83
Today
US$117
31/10
US$124
01/11
US$74
02/11
US$92
03/11
No data
04/11
No data
busbud logoThe cheapest trip from Chicago to Greenville, SC was searched and found on 01 Nov 2025 with a price of US$74

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC as early as possible.

You can expect to pay from US$74 to US$213 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$74, which is on 2025-11-01.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Greenville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to Greenville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Chicago to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Chicago to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from Greenville, SC to Chicago

You can also go to Greenville, SC by train

Train from Chicago to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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