Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago 95Th & Dan Ryan | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | 537-517 W. Jackson Blvd | 1116 Woodruff Rd | Fastest | ||||
| Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags | ||||
| Bus | Downtown Greyhound Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Today at 1:27 PM CST.
Compare 2 ways to go from Chicago to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 20 hours 56 minutes, and with fares starting at just $127, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Greenville?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Compare bus companies
Frequently asked questions about travelling from Chicago to Greenville, SC by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Greenville?
The cheapest bus tickets from Chicago to Greenville start from $127. The average price for this route is around $203. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Greenville?
The average bus travel time from Chicago to Greenville is 20h 56m, covering a distance of 911 km. The quickest bus can get you there in 20h 5m and is operated by Greyhound.
Which bus companies service the Chicago to Greenville route?
What are the earliest and latest departure times for the bus from Chicago to Greenville?
The earliest bus departs from Chicago to Greenville at 5:25am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from Chicago to Greenville?
A bus trip from Chicago to Greenville generates an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to Greenville?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11504 reviews.
Which bus company has the best Wi-Fi from Chicago to Greenville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Greenville, SC was searched and found on Dec 14, 2025 with a price of $166To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC, as early as possible.
You can expect to pay from $166 to $267 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $166 which is on 2025-12-14.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Chicago to Greenville, SC?
The bus is the cheapest travel choice for this destination
