Bus Tickets from Chicago to Greenville, SC

Next departures

Next departures for Chicago to Greenville on October 9
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Chicago 95Th & Dan Ryan
1116 Woodruff RdCheapest
FlixBus
Downtown Greyhound Station
1116 Woodruff RdFastest
FlixBus
Downtown Greyhound Station
1116 Woodruff RdNo tags
Greyhound Lines, Inc. + FlixBus
537-517 W. Jackson Blvd
1116 Woodruff RdNo tags
FlixBus
Chicago 95Th & Dan Ryan
1116 Woodruff RdNo tags

Last refresh of the prices: Yesterday at 7:24 PM CDT.

Accepted payments

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  • China Union Pay
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Compare 2 ways to go from Chicago to Greenville.

Bus
Average Price$73 - $288Average Duration20h 50m
22kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$197 - $451Average Duration1d 9h
82kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Chicago to Greenville

Among the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 20 hours 50 minutes and with fares starting at just $73, it presents an excellent value for a comfortable ride.

14bus per day
20h 50mAverage Duration
$73Cheapest ticket
22kgCO₂ emissions

Bus Chicago to Greenville, SC: Trip Overview

Average ticket price$105
Average bus trip duration20h 50m
Number of daily buses14
Earliest bus departure12:30am
Distance556 miles (896 km)
Latest bus departure11:59pm

Chicago to Greenville Bus

Busbud helps you find a bus from Chicago to Greenville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Chicago to Greenville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from Chicago to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Chicago - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/07
$92
10/08
$150
Today
$131
10/10
No data
10/11
$84
10/12
$88
10/13
$83
10/14
$103
busbud logoThe cheapest trip from Chicago to Greenville, SC was searched and found on Oct 13, 2025 with a price of $83

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Greenville, SC, as early as possible.

You can expect to pay from $83 to $284 for a bus ticket from Chicago to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $83 which is on 2025-10-13.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Greenville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to Greenville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Chicago to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Chicago to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from Greenville, SC to Chicago

You can also go to Greenville, SC by train

Train from Chicago to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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