Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 537-517 W. Jackson Blvd | Knoxville Bus Station | Cheapest | ||||
| Bus | Downtown Greyhound Station | Knoxville Bus Station | Fastest | ||||
| Bus | Downtown Greyhound Station | Knoxville Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Knoxville Bus Station | No tags | ||||
| Bus | Chicago 95Th & Dan Ryan | Knoxville Bus Station | No tags |
Last refresh of the prices: Yesterday at 4:38 PM CST.
Get from Chicago to Knoxville
The journey takes about 19 hours 45 minutes, and with fares starting at just R 1 654, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Knoxville?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- B
Chicago O'Hare International Airport
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Frequently asked questions about travelling from Chicago to Knoxville, TN by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Chicago to Knoxville?
The cheapest bus tickets from Chicago to Knoxville start at R 1 654. The average price for this route is around R 2 606. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Chicago to Knoxville?
The average bus journey time from Chicago to Knoxville is 19h 45m, covering a distance of 715 km. The fastest bus gets you there in 15h 30m and is operated by Greyhound.
Which bus companies service the Chicago to Knoxville route?
What is the earliest and latest departure time for the bus from Chicago to Knoxville?
The earliest bus departs from Chicago to Knoxville at 05:25. And the latest bus departs at 23:59.
What are the CO₂ emissions for the bus trip from Chicago to Knoxville?
A bus trip from Chicago to Knoxville produces an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Chicago to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87412 reviews.
Which bus company has the best Wi-Fi from Chicago to Knoxville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Chicago to Knoxville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Knoxville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Knoxville, TN was searched and found on 15 Dec 2025 with a price of R 1 704To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN as early as possible.
You can expect to pay from R 1 704 to R 3 110 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 704, which is on 2025-12-15.
