Cheap buses leaving Wednesday
One passenger / one way
- This trip is recommended because it is the: Cheapest
- This trip is recommended because it is the: FastestDeparture time: June 18 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: June 18 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: June 18 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: June 18 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: June 18 atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: June 19 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
Last refresh of the prices: Last Wednesday at 4:14 AM CDT.
Prices and availability are subject to change.
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Bus Chicago to Knoxville: Trip Overview
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Chicago to Knoxville Bus
Busbud helps you find a bus from Chicago to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Knoxville.
Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Chicago, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Chicago and Knoxville?
Frequently asked questions on the trip Chicago - Knoxville (TN)
How long does it take to get to Knoxville from Chicago by bus?
The typical travel time from Chicago to Knoxville by bus is around 21h 50m. The fastest bus on this trip will get to Knoxville in 15h 15m
What is the distance between Chicago and Knoxville?
The distance covered from Chicago to Knoxville is 731 km (454 miles).
What are the departure and arrival locations for buses traveling from Chicago to Knoxville?
Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at 100 Kirkwood St, in Knoxville.
What is the cheapest way to go from Chicago to Knoxville?
Taking the bus is the cheapest option to travel from Chicago to Knoxville. With a starting ticket price of US$84, this bus becomes your top pick for this journey.
How much is the bus from Chicago to Knoxville?
The bus fare from Chicago to Knoxville is approximately US$119.
Is it possible to travel by overnight bus from Chicago to Knoxville?
Yes! Catch buses leaving from Chicago until 11:59pm and reaching Knoxville on the following day.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Knoxville was searched and found on Jun 19, 2025 with a price of US$88To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, as early as possible.
You can expect to pay from US$88 to US$226 for a bus ticket from Chicago to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$88 which is on 2025-06-19.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Knoxville!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Knoxville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Knoxville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Knoxville.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
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