Find coaches from Des Moines to San Francisco, US

Previously seen journeys

Next departures from Des Moines to San Francisco on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Des Moines (Subway)
Hyde/Beach (Fisherman's Wharf)No tags
Greyhound + FlixBus
Des Moines (Subway)
Daly BART - 500 John Daly BlvdNo tags
FlixBus + Greyhound
Des Moines (Subway)
409 Townsend St, SFNo tags
Greyhound + FlixBus
Des Moines (Subway)
San Francisco Bus StationNo tags
Greyhound + FlixBus
Des Moines (Subway)
409 Townsend St, SFNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Get from Des Moines to San Francisco

busbud logoThis route is served by bus only

The journey takes about 2 days, 50 minutes, and with fares starting at just US$232, it presents an excellent value for a comfortable ride.

2bus per day
2d Average duration
2489 kmDistance
62kgCO₂ emissions

Bus Des Moines to San Francisco, US: Trip Overview

Average ticket priceUS$276
Average bus trip duration2d
Number of daily buses2
Earliest bus departure19:15
Distance2489 km

Des Moines to San Francisco Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Des Moines to San Francisco.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to San Francisco.

Whether it is cheap bus tickets or more luxurious buses going to San Francisco from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Des Moines - San Francisco, US

  1. How much does a bus ticket from Des Moines to San Francisco cost?

    The bus ticket price from Des Moines to San Francisco starts at US$232. The best way to find cheap bus tickets from Des Moines to San Francisco is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Des Moines to San Francisco?

    The average travel time between Des Moines and San Francisco is around 2d , although the fastest bus will take about 1d 19h. This is the time it takes to travel the 2493 km that separates the two cities.

  3. How many daily bus connections are there between Des Moines and San Francisco?

    The number of buses from Des Moines to San Francisco can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Des Moines to San Francisco by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Des Moines to San Francisco?

    When taking the bus from Des Moines to San Francisco, you can travel comfortably and safely with Greyhound.

  5. What are the departure and arrival stations when taking the bus from Des Moines to San Francisco?

    Buses travelling between Des Moines and San Francisco leave from Jefferson/Trailways Depot or 1514 East Grand Ave and arrive at Hyde/Beach (Fisherman's Wharf), Powell Station, Union Square Hilton.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$237
29/10
US$255
Today
US$233
31/10
No data
01/11
No data
02/11
No data
03/11
No data
04/11
No data
busbud logoThe cheapest trip from Des Moines to San Francisco, US was searched and found on 30 Oct 2025 with a price of US$233

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to San Francisco, US as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Des Moines to San Francisco but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to San Francisco.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to San Francisco.

Make a music playlist for your bus ride from Des Moines to San Francisco, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Des Moines by bus?

Bus from San Francisco, US to Des Moines

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Des Moines

Buses Leaving from Des Moines

Buses Going to Des Moines

Popular Buses Connecting San Francisco

Buses Leaving from San Francisco

Buses Going to San Francisco