Bus Tickets from Des Moines to San Francisco, US

Previously seen trips

Next departures for Des Moines to San Francisco on October 13
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Des Moines (Subway)
Daly BART - 500 John Daly BlvdNo tags
Greyhound + FlixBus
Des Moines (Subway)
409 Townsend St, SFNo tags
Greyhound + FlixBus
Des Moines (Subway)
Hyde/Beach (Fisherman's Wharf)No tags
Greyhound + FlixBus
Des Moines (Subway)
409 Townsend St, SFNo tags
Greyhound + FlixBus
Des Moines (Subway)
San Francisco Bus StationNo tags

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Bus Des Moines to San Francisco, US: Trip Overview

Average Ticket PriceUS$277
Average Bus Trip Duration3d 3h
Number of daily buses2
Earliest bus departure5:30am
Distance2489 km

Des Moines to San Francisco Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Des Moines to San Francisco.

We make it our job to connect you with the most dependable bus companies that cover bus service from Des Moines to San Francisco.

Whether it is cheap bus tickets or more luxurious buses going to San Francisco from Des Moines, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Des Moines - San Francisco, US

  1. What is the distance between Des Moines and San Francisco?

    The distance between Des Moines and San Francisco is around 2493 km (1546 miles).

  2. What are the departure and arrival locations for buses traveling from Des Moines to San Francisco?

    Buses traveling this route start their trip at Jefferson/Trailways Depot, in Des Moines, and end it at Hyde/Beach (Fisherman's Wharf), in San Francisco.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-11
US$268
10-12
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Today
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10-14
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10-15
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10-16
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10-17
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10-18
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busbud logoThe cheapest trip from Des Moines to San Francisco, US was searched and found on Oct 11, 2025 with a price of US$268

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to San Francisco, US, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Des Moines to San Francisco but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Des Moines to San Francisco.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Des Moines to San Francisco.

Make a music playlist for your bus ride from Des Moines to San Francisco, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Des Moines by bus?

Bus from San Francisco, US to Des Moines

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