How much is the bus ticket from Greenville to Chicago?

The cheapest bus tickets from Greenville to Chicago start at R 1 601. The average price for this route is around R 2 503. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

How long is the bus journey from Greenville to Chicago?

The average bus journey time from Greenville to Chicago is 21h 30m, covering a distance of 911 km. The fastest bus gets you there in 20h 55m and is operated by Greyhound .

Which bus companies service the Greenville to Chicago route?

Several major bus companies operate on this route with 11 buses available per day, including services from FlixBus , Greyhound .

What is the earliest and latest departure time for the bus from Greenville to Chicago?

The earliest bus departs from Greenville to Chicago at 13:20. And the latest bus departs at 22:00.

What are the CO₂ emissions for the bus trip from Greenville to Chicago?

A bus trip from Greenville to Chicago produces an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

What is the best bus company from Greenville to Chicago?

According to Busbud customers, the highest-rated bus company on this route is FlixBus , with an average rating of 3.5 out of 5 stars based on 12208 reviews.

Which bus company has the best Wi-Fi from Greenville to Chicago?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company offers the most punctual service from Greenville to Chicago?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 4.0 out of 5 stars.

Which bus company has the cleanest buses from Greenville to Chicago?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to Chicago from R 1 377 | Refundable Tickets

Next bus departures

Next departures from Greenville to Chicago on 16 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	22:00	1116 Woodruff Rd	1d 2h	23:50	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	19:40	1116 Woodruff Rd	20h 35m	15:15	Downtown Greyhound Station	Fastest
	Bus	17:45	1116 Woodruff Rd	21h 50m	14:35	Downtown Greyhound Station	No tags
	Bus	22:00	1116 Woodruff Rd	1d 3h	00:10	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	22:00	1116 Woodruff Rd	1d 11h	08:00	537-517 W. Jackson Blvd	No tags

Next departures from Greenville to Chicago on 17 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	14:45	1116 Woodruff Rd	21h 20m	11:05	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	19h 40m	08:00	537-517 W. Jackson Blvd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	20h 5m	08:25	Downtown Greyhound Station	No tags
	Bus	14:45	1116 Woodruff Rd	1d	14:10	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:45	1116 Woodruff Rd	21h 45m	11:30	Downtown Greyhound Station	No tags

Next departures from Greenville to Chicago on 18 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	14:45	1116 Woodruff Rd	21h 20m	11:05	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	19h 40m	08:00	537-517 W. Jackson Blvd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	20h 5m	08:25	Downtown Greyhound Station	No tags
	Bus	14:45	1116 Woodruff Rd	1d	14:10	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	14:45	1116 Woodruff Rd	21h 45m	11:30	Downtown Greyhound Station	No tags

Next departures from Greenville to Chicago on 19 February
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	21h 30m	09:50	Chicago 95Th & Dan Ryan	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	19h 40m	08:00	537-517 W. Jackson Blvd	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	13:20	1116 Woodruff Rd	20h 5m	08:25	Downtown Greyhound Station	No tags
	Bus	22:00	1116 Woodruff Rd	1d 3h	00:10	Downtown Greyhound Station	No tags
	Bus	14:45	1116 Woodruff Rd	1d	14:10	537-517 W. Jackson Blvd	No tags

Last refresh of the prices: Yesterday at 2:11 AM EST.

Compare 2 ways to travel from Greenville to Chicago

We recommend taking the bus

Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just R 1 601, it presents an excellent value for a comfortable ride.

11bus per day

21h 30mAverage duration

911 kmDistance

23kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceR 1 601 - R 5 330	Average duration21h 30m	CO₂ emissions 23kg CO₂e
Train	Average priceR 2 887 - R 16 069	Average duration1d 7h	CO₂ emissions 82kg CO₂e

Where are the popular stops in Greenville and Chicago?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

FlixBus

3.5/512 217 reviews

Staff4.2

Timeliness4

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 523 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

WiFi2.5

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Greenville, SC to Chicago by bus

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

How much is the bus ticket from Greenville to Chicago?
The cheapest bus tickets from Greenville to Chicago start at R 1 601. The average price for this route is around R 2 503. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Greenville to Chicago?
The average bus journey time from Greenville to Chicago is 21h 30m, covering a distance of 911 km. The fastest bus gets you there in 20h 55m and is operated by Greyhound.
Which bus companies service the Greenville to Chicago route?
Several major bus companies operate on this route with 11 buses available per day, including services from FlixBus, Greyhound.
What is the earliest and latest departure time for the bus from Greenville to Chicago?
The earliest bus departs from Greenville to Chicago at 13:20. And the latest bus departs at 22:00.
What are the CO₂ emissions for the bus trip from Greenville to Chicago?
A bus trip from Greenville to Chicago produces an estimated 23 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Greenville to Chicago?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 12208 reviews.
Which bus company has the best Wi-Fi from Greenville to Chicago?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Greenville to Chicago?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Chicago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

14/02

R 3 639

15/02

R 3 458

Today

R 3 565

17/02

R 3 541

18/02

R 3 344

19/02

R 2 147

20/02

R 1 377

21/02

No data

The cheapest trip from Greenville, SC to Chicago was searched and found on 20 Feb 2026 with a price of R 1 377

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago as early as possible.

You can expect to pay from R 1 377 to R 4 319 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at R 1 377, which is on 2026-02-20.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.