Find coaches from Greenville, SC to Chicago

Next departures

Next departures from Greenville to Chicago on 31 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Downtown Greyhound StationCheapest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
537-517 W. Jackson BlvdFastest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Downtown Greyhound StationNo tags
FlixBus
1116 Woodruff Rd
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
1116 Woodruff Rd
537-517 W. Jackson BlvdNo tags

Last refresh of the prices: Yesterday at 11:53 AM EDT.

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Compare 2 ways to travel from Greenville to Chicago

busbud logoWe recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 21 hours 25 minutes and with fares starting at just US$78, it presents an excellent value for a comfortable ride.

12bus per day
21h 25mAverage duration
911 kmDistance
23kgCO₂ emissions
Bus
Average priceUS$78 - US$294Average duration21h 25m
23kg CO₂e
Train
Average priceUS$177 - US$2 129Average duration1d 7h
82kg CO₂e

Bus Greenville, SC to Chicago: Trip Overview

Average ticket priceUS$129
Average bus trip duration21h 25m
Number of daily buses12
Earliest bus departure11:15
Distance911 km
Latest bus departure22:00

Greenville to Chicago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Chicago.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville, SC - Chicago

  1. How much does a bus ticket from Greenville to Chicago cost?

    The bus ticket price from Greenville to Chicago starts at US$78. The best way to find cheap bus tickets from Greenville to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Greenville to Chicago?

    The average travel time between Greenville and Chicago is around 21h 25m, although the fastest bus will take about 18h 25m. This is the time it takes to travel the 904 km that separates the two cities.

  3. How many daily bus connections are there between Greenville and Chicago?

    The number of buses from Greenville to Chicago can differ depending on the day of the week. On average, there are 12 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Greenville to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Greenville to Chicago?

    When taking the bus from Greenville to Chicago, you can travel comfortably and safely with FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Greenville to Chicago?

    Buses travelling between Greenville and Chicago leave from Guadalajara Supermarket Bus Stop or Greenville Bus Station and arrive at Downtown Greyhound Station, Chicago O'Hare International Airport, Polk St & Canal St.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/10
US$149
29/10
US$250
Today
US$137
31/10
US$110
01/11
US$133
02/11
US$90
03/11
US$112
04/11
No data
busbud logoThe cheapest trip from Greenville, SC to Chicago was searched and found on 02 Nov 2025 with a price of US$90

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago as early as possible.

You can expect to pay from US$90 to US$250 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$90, which is on 2025-11-02.

Usually FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Chicago.

Make a music playlist for your bus ride from Greenville to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville, SC to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Chicago to Greenville, SC

You can also go to Chicago by train

Train from Greenville, SC to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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