Find coaches from Indianapolis to Greenville, SC

Previously seen journeys

Next departures from Indianapolis to Greenville on 1 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
    		Indianapolis Bus Station
    		1116 Woodruff RdNo tags
    Greyhound
      		Indianapolis Bus Station
      		1116 Woodruff RdNo tags
      Greyhound + FlixBus
        		Downtown Transit Center
        		1116 Woodruff RdNo tags
        FlixBus + Greyhound
          		Downtown Transit Center
          		1116 Woodruff RdNo tags
          FlixBus + Greyhound
            		Indianapolis Bus Station
            		1116 Woodruff RdNo tags

            Accepted payments

            • Visa
            • MasterCard
            • American Express
            • China Union Pay
            • Diners Club Canada
            • Discover Click to Pay
            • JCB payment
            • Klarna (Pay over time)
            • Google Pay

            Compare 2 ways to travel from Indianapolis to Greenville

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes and with fares starting at just US$70, it presents an excellent value for a comfortable ride.

            6bus per day
            16h 15mAverage duration
            646 kmDistance
            16kgCO₂ emissions
            Bus
            		Average priceUS$70 - US$190Average duration16h 15m
            16kg CO₂e
            Train
            		Average priceUS$156 - US$1 451Average duration1d 5h
            58kg CO₂e

            Bus Indianapolis to Greenville, SC: Trip Overview

            Average ticket priceUS$103
            Average bus trip duration16h 15m
            Number of daily buses6
            Earliest bus departure03:40
            Distance646 km
            Latest bus departure23:30

            Indianapolis to Greenville Bus

            With Busbud, comparing and booking tickets for a bus from Indianapolis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make sure you can find a bus service from Indianapolis to Greenville from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to Greenville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip Indianapolis - Greenville, SC

            1. How much does a bus ticket from Indianapolis to Greenville cost?

              The bus ticket price from Indianapolis to Greenville starts at US$70. The best way to find cheap bus tickets from Indianapolis to Greenville is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Indianapolis to Greenville?

              The average travel time between Indianapolis and Greenville is around 16h 15m, although the fastest bus will take about 15h 15m. This is the time it takes to travel the 641 km that separates the two cities.

            3. How many daily bus connections are there between Indianapolis and Greenville?

              The number of buses from Indianapolis to Greenville can differ depending on the day of the week. On average, there are 6 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Indianapolis to Greenville by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Indianapolis to Greenville?

              When taking the bus from Indianapolis to Greenville, you can travel comfortably and safely with FlixBus, Greyhound.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            30/10
            No data
            31/10
            US$97
            Today
            No data
            02/11
            US$86
            03/11
            No data
            04/11
            No data
            05/11
            US$81
            06/11
            No data
            busbud logoThe cheapest trip from Indianapolis to Greenville, SC was searched and found on 05 Nov 2025 with a price of US$81

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC as early as possible.

            You can expect to pay from US$81 to US$100 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$81, which is on 2025-11-05.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from Indianapolis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Greenville, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Greenville.

            Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Greenville while indulging in miles on end of beautiful scenic views.

            Did you know?

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            What's the cheapest way to go from Indianapolis to Greenville, SC?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Indianapolis by bus?

            Bus from Greenville, SC to Indianapolis

            You can also go to Greenville, SC by train

            Train from Indianapolis to Greenville, SC

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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