Bus Tickets from Indianapolis to Greenville (SC)

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Compare 2 ways to go from Indianapolis to Greenville

Bus
Average PriceUS$73 - US$208Average Duration16h 20m
16kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$155 - US$314Average Duration1d 5h
58kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 20 minutes, and with fares starting at just US$73, it presents an excellent value for a comfortable ride.

6bus per day
16h 20mAverage Duration
US$73Cheapest ticket
16kgCO₂ emissions

Bus Indianapolis to Greenville: Trip Overview

Average Ticket PriceUS$114
Average Bus Trip Duration16h 20m
Number of daily buses6
Earliest bus departure3:15am
Distance646 km
Latest bus departure11:55pm

Indianapolis to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to Greenville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Indianapolis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Indianapolis - Greenville (SC)

  1. How long does it take to get to Greenville from Indianapolis by bus?

    The typical travel time from Indianapolis to Greenville by bus is around 16h 20m. For the shortest travel time, select the fastest bus available, which will take you to Greenville in about 15h 45m.

  2. What is the distance between Indianapolis and Greenville?

    The distance covered from Indianapolis to Greenville is 641 km (398 miles).

  3. What are the departure and arrival locations for buses traveling from Indianapolis to Greenville?

    Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

  4. What is the cheapest way to go from Indianapolis to Greenville?

    The least expensive way to go from Indianapolis to Greenville would be going by bus. With a starting ticket price of US$73, this bus becomes your top pick for this journey.

  5. How much is the bus from Indianapolis to Greenville?

    The bus fare from Indianapolis to Greenville is approximately US$114.

  6. Is it possible to travel by overnight bus from Indianapolis to Greenville?

    Yes! Catch buses leaving from Indianapolis until 11:55pm and reaching Greenville on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
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05-21
US$109
Today
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busbud logoThe cheapest trip from Indianapolis to Greenville was searched and found on May 21, 2025 with a price of US$109

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to Greenville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Indianapolis to Greenville.

Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Greenville while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from Indianapolis to Greenville?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Indianapolis to Greenville

You can also go to Greenville by train

Train from Indianapolis to Greenville

Why choose Busbud?

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