Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Transit Center | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Indianapolis Bus Station | 1116 Woodruff Rd | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | 1116 Woodruff Rd | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 18:14 EST.
Compare 2 ways to travel from Indianapolis to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes and with fares starting at just £68, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Greenville?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling by bus from Indianapolis to Greenville, SC
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Indianapolis to Greenville?
The cheapest coach tickets from Indianapolis to Greenville start from £68. The average price for this route is around £115. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Indianapolis to Greenville?
The average bus journey time from Indianapolis to Greenville is 16h 15m, covering a distance of 401 miles. The fastest bus can take you there in 15h 15m and is operated by Greyhound.
Which bus companies service the Indianapolis to Greenville route?
What is the earliest and latest departure time for the bus from Indianapolis to Greenville?
The earliest bus departs from Indianapolis to Greenville at 03:40. And the latest bus departs at 23:30.
What are the CO₂ emissions for the bus trip from Indianapolis to Greenville?
A bus journey from Indianapolis to Greenville produces an estimated 16 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Indianapolis to Greenville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which company has the best Wi-Fi from Indianapolis to Greenville?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Indianapolis to Greenville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Greenville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Greenville, SC was searched and found on 9 Jan 2026 with a price of £88To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC as early as possible.
You can expect to pay from £88 to £132 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £88, which is on 2026-01-09.
What's the cheapest way to go from Indianapolis to Greenville, SC?
The Bus is the cheapest travel choice for this destination
