How much is the bus ticket from Indianapolis to San Diego?

The cheapest bus tickets from Indianapolis to San Diego start at R 2 309. The average price for this route is around R 6 335. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

How long is the bus journey from Indianapolis to San Diego?

The average bus journey time from Indianapolis to San Diego is 2d 11h, covering a distance of 2874 km. The fastest bus gets you there in 2d and is operated by Greyhound .

Which bus companies service the Indianapolis to San Diego route?

Several major bus companies operate on this route with 19 buses available per day, including services from Greyhound , FlixBus , Amtrak .

What is the earliest and latest departure time for the bus from Indianapolis to San Diego?

The earliest bus departs from Indianapolis to San Diego at 03:15. And the latest bus departs at 23:30.

What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?

A bus trip from Indianapolis to San Diego produces an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

What is the best bus company from Indianapolis to San Diego?

According to Busbud customers, the highest-rated bus company on this route is Amtrak , with an average rating of 4.1 out of 5 stars based on 5627 reviews.

Which bus company has the best Wi-Fi from Indianapolis to San Diego?

Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

Which bus company offers the most punctual service from Indianapolis to San Diego?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Indianapolis to San Diego?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak , with a cleanliness rating of 4.5 out of 5 stars.

Bus Indianapolis to San Diego from R 3 742 | Refundable Tickets

Next bus departures

Next departures from Indianapolis to San Diego on 16 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	23:30	Downtown Transit Center	2d 17h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d 6h	23:50	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	3d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 17 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	08:35	Downtown Transit Center	2d 8h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 18 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	08:35	Downtown Transit Center	2d 8h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 19 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	23:30	Downtown Transit Center	2d 17h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 21 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 8h	16:25	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d	17:45	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	3d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 22 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	3d 1h	18:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 8h	16:25	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d 6h	23:50	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Next departures from Indianapolis to San Diego on 23 December
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25	Indianapolis Bus Station	2d 5h	14:10	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d	17:35	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	20:05	Indianapolis Bus Station	2d 1h	18:10	San Diego (Old Town-FlixBus)	No tags
	Bus	20:05	Indianapolis Bus Station	2d 6h	23:50	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	20:10	Indianapolis Bus Station	3d 1h	18:10	San Diego (Old Town-FlixBus)	No tags

Last refresh of the prices: Last Saturday at 12:12 AM EST.

Compare 2 ways to travel from Indianapolis to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 11 hours 5 minutes and with fares starting at just R 2 309, it presents an excellent value for a comfortable ride.

19bus per day

2d 11hAverage duration

2874 kmDistance

72kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceR 2 309 - R 11 428	Average duration2d 11h	CO₂ emissions 72kg CO₂e
Train	Average priceR 3 868 - R 30 367	Average duration2d 9h	CO₂ emissions 261kg CO₂e

Where are the popular stops in Indianapolis and San Diego?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587 434 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

FlixBus

3.5/511 629 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

WiFi2.7

Amtrak

4/55 651 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

WiFi3.6

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Indianapolis to San Diego, CA, US by bus

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

How much is the bus ticket from Indianapolis to San Diego?
The cheapest bus tickets from Indianapolis to San Diego start at R 2 309. The average price for this route is around R 6 335. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Indianapolis to San Diego?
The average bus journey time from Indianapolis to San Diego is 2d 11h, covering a distance of 2874 km. The fastest bus gets you there in 2d and is operated by Greyhound.
Which bus companies service the Indianapolis to San Diego route?
Several major bus companies operate on this route with 19 buses available per day, including services from Greyhound, FlixBus, Amtrak.
What is the earliest and latest departure time for the bus from Indianapolis to San Diego?
The earliest bus departs from Indianapolis to San Diego at 03:15. And the latest bus departs at 23:30.
What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?
A bus trip from Indianapolis to San Diego produces an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Indianapolis to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from Indianapolis to San Diego?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Indianapolis to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

14/12

R 5 067

15/12

R 5 756

Today

R 7 760

17/12

R 8 104

18/12

R 8 207

19/12

R 8 448

20/12

R 3 742

21/12

R 8 379

The cheapest trip from Indianapolis to San Diego, CA, US was searched and found on 20 Dec 2025 with a price of R 3 742

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US as early as possible.

You can expect to pay from R 3 742 to R 8 448 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 3 742, which is on 2025-12-20.