How much is the bus ticket from Indianapolis to San Diego?

The cheapest bus tickets from Indianapolis to San Diego start from $190. The average price for this route is around $520. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Indianapolis to San Diego?

The average bus travel time from Indianapolis to San Diego is 2d 11h, covering a distance of 2874 km. The quickest bus can get you there in 2d and is operated by Greyhound .

Which bus companies service the Indianapolis to San Diego route?

Several major bus companies operate on this route with 19 buses available per day, including services from Greyhound , FlixBus , Amtrak .

What are the earliest and latest departure times for the bus from Indianapolis to San Diego?

The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:30pm.

What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?

A bus trip from Indianapolis to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

What is the best bus company from Indianapolis to San Diego?

According to Busbud customers, the highest-rated bus company on this route is Amtrak , with an average rating of 4.1 out of 5 stars based on 5627 reviews.

Which bus company has the best Wi-Fi from Indianapolis to San Diego?

Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.

Which bus company has the best on-time performance from Indianapolis to San Diego?

According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Indianapolis to San Diego?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak , with a cleanliness rating of 4.5 out of 5 stars.

Bus Indianapolis to San Diego from $413 | Refundable Tickets

Next bus departures

Next departures for Indianapolis to San Diego on December 17
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	1:40pm	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	8:35am	Downtown Transit Center	2d 8h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:30pm	Downtown Transit Center	2d 17h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 20
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:30pm	Downtown Transit Center	2d 13h	9:40am	UCSD Health La Jolla Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	2:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 8h	4:25pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d	5:45pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:10pm	Indianapolis Bus Station	3d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 22
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:10pm	Indianapolis Bus Station	3d 1h	6:10pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 8h	4:25pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d 6h	11:50pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Next departures for Indianapolis to San Diego on December 23
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:25am	Indianapolis Bus Station	2d 5h	2:10pm	San Diego (Old Town-FlixBus)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d	5:35pm	UCSD Health La Jolla Station	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Indianapolis Bus Station	2d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags
	Bus	8:05pm	Indianapolis Bus Station	2d 6h	11:50pm	Greyhound Bus Stop	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:10pm	Indianapolis Bus Station	3d 1h	6:10pm	San Diego (Old Town-FlixBus)	No tags

Last refresh of the prices: Last Sunday at 1:32 AM EST.

Compare 2 ways to go from Indianapolis to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 11 hours 5 minutes, and with fares starting at just $190, it presents an excellent value for a comfortable ride.

19bus per day

2d 11hAverage Duration

2874 kmDistance

72kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$190 - $939	Average Duration2d 11h	CO₂ emissions 72kg CO₂e
Train	Average Price$318 - $2,493	Average Duration2d 9h	CO₂ emissions 261kg CO₂e

Where are the popular stops in Indianapolis and San Diego?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,435 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,631 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Amtrak

4/55,652 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Indianapolis to San Diego, CA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Indianapolis to San Diego?
The cheapest bus tickets from Indianapolis to San Diego start from $190. The average price for this route is around $520. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to San Diego?
The average bus travel time from Indianapolis to San Diego is 2d 11h, covering a distance of 2874 km. The quickest bus can get you there in 2d and is operated by Greyhound.
Which bus companies service the Indianapolis to San Diego route?
Several major bus companies operate on this route with 19 buses available per day, including services from Greyhound, FlixBus, Amtrak.
What are the earliest and latest departure times for the bus from Indianapolis to San Diego?
The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?
A bus trip from Indianapolis to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5627 reviews.
Which bus company has the best Wi-Fi from Indianapolis to San Diego?
Based on Busbud reviews, the bus company Amtrak has the highest Wi-Fi rating with a score of 3.6.
Which bus company has the best on-time performance from Indianapolis to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-15

$473

12-16

$638

Today

$666

12-18

$674

12-19

$694

12-20

$722

12-21

$688

12-22

$539

The cheapest trip from Indianapolis to San Diego, CA, US was searched and found on Dec 15, 2025 with a price of $473

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US, as early as possible.

You can expect to pay from $473 to $722 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $539 which is on 2025-12-22.