Bus Tickets from Indianapolis, IN to San Diego, CA

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TodayMay 7
from $313
TomorrowMay 8
FriMay 9
SatMay 10
SunMay 11
MonMay 12
TueMay 13
WedMay 14

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: May 7 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: May 9 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 7 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: May 10 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from Indianapolis to San Diego.

Bus
Average Price$117 - $508Average Duration2d 12h
72kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$207 - $346Average Duration2d 9h
262kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Indianapolis to San Diego

Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 2 days, 9 hours 53 minutes and with fares starting at just $207, it presents an excellent value for a comfortable ride.

2train per day
2d 9hAverage Duration
$207Cheapest ticket
262kgCO₂ emissions

Bus Indianapolis to San Diego: Trip Overview

Average ticket price$230
Average bus trip duration2d 12h
Number of daily buses24
Earliest bus departure3:15am
Distance1790 miles (2886 km)
Latest bus departure11:55pm

Indianapolis to San Diego Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to San Diego from the most reliable bus companies operating this trip.

Discover how much the bus trip from Indianapolis to San Diego will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Indianapolis - San Diego

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/05
No data
05/06
$345
Today
$313
05/08
No data
05/09
No data
05/10
No data
05/11
$225
05/12
No data
busbud logoThe cheapest trip from Indianapolis to San Diego was searched and found on May 11, 2025 with a price of $225

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, as early as possible.

You can expect to pay from $225 to $391 for a bus ticket from Indianapolis to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at $225 which is on 2025-05-11.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Indianapolis to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to San Diego, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to San Diego will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Indianapolis to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Indianapolis by bus?

Bus from Indianapolis to San Diego

You can also go to San Diego by train

Train from Indianapolis to San Diego

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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