Bus from Indianapolis to San Diego, CA, US: Tickets & Schedules

Previously seen trips

Next departures for Indianapolis to San Diego on November 28
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
Bus
Downtown Transit Center
Balboa ParkNo tags
FlixBus + Greyhound
Bus
Downtown Transit Center
UCSD Health La Jolla StationNo tags
Greyhound + FlixBus
Bus
Downtown Transit Center
Greyhound Bus StopNo tags
Greyhound + FlixBus
Bus
Downtown Transit Center
Downtown SD (Seaport)No tags
FlixBus + Greyhound
Bus
Downtown Transit Center
San Diego (Old Town-FlixBus)No tags

Compare 2 ways to go from Indianapolis to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 13 hours 10 minutes and with fares starting at just $169, it presents an excellent value for a comfortable ride.

22bus per day
2d 13hAverage Duration
1782 milesDistance
72kgCO₂ emissions
Average Price$169 - $590Average Duration2d 13h
72kg CO₂e
Average Price$361 - $1,999Average Duration2d 9h
261kg CO₂e

Frequently asked questions about traveling from Indianapolis to San Diego, CA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

  1. How much is the bus ticket from Indianapolis to San Diego?

    The cheapest bus tickets from Indianapolis to San Diego start from $169. The average price for this route is around $260. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

  2. How long is the bus ride from Indianapolis to San Diego?

    The average bus trip duration from Indianapolis to San Diego is 2d 13h, covering a distance of 1782 miles (2874 km). The quickest bus can get you there in 2d and is operated by Greyhound.

  3. Which bus companies service the Indianapolis to San Diego route?

    Several major bus companies operate on this route with 22 buses available per day, including services from Greyhound, FlixBus, Amtrak.

  4. What is the earliest and latest departure time for the bus from Indianapolis to San Diego?

    The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:30pm.

  5. What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?

    A bus trip from Indianapolis to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

  6. What is the best bus company from Indianapolis to San Diego?

    According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.

  7. Which bus company has the best Wi-Fi from Indianapolis to San Diego?

    Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

  8. Which bus company has the most timely service from Indianapolis to San Diego?

    According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.

  9. Which bus company has the cleanest buses from Indianapolis to San Diego?

    According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/26
$465
11/27
No data
Today
No data
11/29
No data
11/30
No data
12/01
No data
12/02
$152
12/03
No data
busbud logoThe cheapest trip from Indianapolis to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $152

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US, as early as possible.

You can expect to pay from $152 to $465 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $152 which is on 2025-12-02.

What's the cheapest way to go from Indianapolis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

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