How much is the bus ticket from Indianapolis to San Diego?

The cheapest bus tickets from Indianapolis to San Diego start from $169. The average price for this route is around $260. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Indianapolis to San Diego?

The average bus trip duration from Indianapolis to San Diego is 2d 13h, covering a distance of 1782 miles (2874 km). The quickest bus can get you there in 2d and is operated by Greyhound .

Which bus companies service the Indianapolis to San Diego route?

Several major bus companies operate on this route with 22 buses available per day, including services from Greyhound , FlixBus , Amtrak .

What is the earliest and latest departure time for the bus from Indianapolis to San Diego?

The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:30pm.

What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?

A bus trip from Indianapolis to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Indianapolis to San Diego?

According to Busbud customers, the highest-rated bus company on this route is Amtrak , with an average rating of 4.1 out of 5 stars based on 5597 reviews.

Which bus company has the best Wi-Fi from Indianapolis to San Diego?

Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.

Which bus company has the most timely service from Indianapolis to San Diego?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Indianapolis to San Diego?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak , with a cleanliness rating of 4.5 out of 5 stars.

Bus Indianapolis to San Diego from $152 | Refundable Tickets

Previously seen trips

Next departures for Indianapolis to San Diego on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	11:30pm	Downtown Transit Center	2d 13h	10:10am	Balboa Park	No tags
FlixBus + Greyhound	Bus	11:30pm	Downtown Transit Center	2d 12h	8:45am	UCSD Health La Jolla Station	No tags
Greyhound + FlixBus	Bus	11:30pm	Downtown Transit Center	2d 13h	9:55am	Greyhound Bus Stop	No tags
Greyhound + FlixBus	Bus	11:30pm	Downtown Transit Center	2d 14h	10:30am	Downtown SD (Seaport)	No tags
FlixBus + Greyhound	Bus	11:30pm	Downtown Transit Center	2d 12h	9:15am	San Diego (Old Town-FlixBus)	No tags

Compare 2 ways to go from Indianapolis to San Diego

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 13 hours 10 minutes and with fares starting at just $169, it presents an excellent value for a comfortable ride.

22bus per day

2d 13hAverage Duration

1782 milesDistance

72kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$169 - $590	Average Duration2d 13h	CO₂ emissions 72kg CO₂e
Train	Average Price$361 - $1,999	Average Duration2d 9h	CO₂ emissions 261kg CO₂e

Where are the popular stops in Indianapolis and San Diego?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Compare bus companies

Greyhound

3.5/587,403 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,465 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Amtrak

4/55,610 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Indianapolis to San Diego, CA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Indianapolis to San Diego?
The cheapest bus tickets from Indianapolis to San Diego start from $169. The average price for this route is around $260. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to San Diego?
The average bus trip duration from Indianapolis to San Diego is 2d 13h, covering a distance of 1782 miles (2874 km). The quickest bus can get you there in 2d and is operated by Greyhound.
Which bus companies service the Indianapolis to San Diego route?
Several major bus companies operate on this route with 22 buses available per day, including services from Greyhound, FlixBus, Amtrak.
What is the earliest and latest departure time for the bus from Indianapolis to San Diego?
The earliest bus departs from Indianapolis to San Diego at 3:15am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to San Diego?
A bus trip from Indianapolis to San Diego generates an estimated 72 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Indianapolis to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.
Which bus company has the best Wi-Fi from Indianapolis to San Diego?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company has the most timely service from Indianapolis to San Diego?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/26

$465

11/27

No data

Today

No data

11/29

No data

11/30

No data

12/01

No data

12/02

$152

12/03

No data

The cheapest trip from Indianapolis to San Diego, CA, US was searched and found on Dec 2, 2025 with a price of $152

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, CA, US, as early as possible.

You can expect to pay from $152 to $465 for a bus ticket from Indianapolis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $152 which is on 2025-12-02.